{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:08:32Z","timestamp":1791115712594,"version":"4.1.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[1997,3,1]],"date-time":"1997-03-01T00:00:00Z","timestamp":857174400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[1997,3]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> The possibility that monoaminergic \nneurotransmission is altered in pathological gambling was examined.<\/jats:p><jats:p><jats:bold>Methods.<\/jats:bold> Monoamines and their metabolites were measured in \nCSF obtained at level L4\u20135 from ten pathological gamblers and \nseven controls.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> A decrease in dopamine and an increase in \n3,4-dihydroxyphenylacetic acid and homovanilic acid was found. \nNoradrenaline and its metabolite 3-methoxy-4-hydroxyphenylglycol was \nalso increased but 5-hydroxytryptamine and 5-hydroxyindoleacetic acid \nwere unchanged.<\/jats:p><jats:p><jats:bold>Conclusion.<\/jats:bold> It is suggested that the function of the \ndopaminergic system, possibly mediating positive and negative reward, \nand the noradrenergic system, possibly mediating selective attention, \nis changed in pathological gambling.<\/jats:p>","DOI":"10.1017\/s0033291796003789","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:33:33Z","timestamp":1027776813000},"page":"473-475","source":"Crossref","is-referenced-by-count":151,"title":["Altered dopamine function in pathological gambling"],"prefix":"10.1017","volume":"27","author":[{"given":"C.","family":"BERGH","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"EKLUND","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"S\u00d6DERSTEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"NORDIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[1997,3,1]]},"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291796003789","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,12]],"date-time":"2019-05-12T19:02:33Z","timestamp":1557687753000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291796003789\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,3]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,3]]}},"alternative-id":["S0033291796003789"],"URL":"https:\/\/doi.org\/10.1017\/s0033291796003789","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,3]]}}}