{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T17:14:59Z","timestamp":1782234899448,"version":"3.54.5"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[1997,3,1]],"date-time":"1997-03-01T00:00:00Z","timestamp":857174400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[1997,3]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> The authors examined data from a \nfollow-up study of first admission schizophrenic patients treated with \nand without antipsychotic medications, who were discharged from the \nhospital within 6 months. It was predicted that patients who did not \nrequire antipsychotic medications for discharge would have a more \nfavourable long-term outcome.<\/jats:p><jats:p><jats:bold>Methods.<\/jats:bold> The subjects were part of the Camarillo State \nHospital study conducted by May and colleagues in the late 1950s and \nearly 1960s. Patients had been randomly assigned to treatment with and \nwithout antipsychotic medications. The number of rehospitalization \ndays and total prescribed chlorpromazine equivalents were calculated \nfor each patient for the 2 years following discharge. In order to \nassess patients' continuing ability to function, 11 patients from \neach group who met DSM-IV criteria for schizophrenia were matched for \nage, educational status at first admission, race, and gender; their \nGlobal Assessment of Functioning Scale (GAF) score was estimated \nacross a period of 6\u20137 years following discharge.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> During the second year following discharge, \npatients initially treated with antipsychotic medications required \nfewer rehospitalization days than the initially non-medicated \npatients. Furthermore, 6\u20137 years following initial discharge, \nthose patients initially treated with medications were functioning at \na higher level, as measured by GAF scores, than patients not initially \ntreated with antipsychotic medications.<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> The results of this study suggest that, at \nleast for this subgroup of patients, early treatment with \nantipsychotic medications both decreases the immediate morbidity \nassociated with schizophrenia, and prevents detrimental changes \npossibly related to prolonged untreated psychosis.<\/jats:p>","DOI":"10.1017\/s0033291796004345","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:33:33Z","timestamp":1027776813000},"page":"261-268","source":"Crossref","is-referenced-by-count":86,"title":["Long-term morbidity associated with delayed treatment of first \nadmission schizophrenic patients: a re-analysis of the Camarillo State \nHospital data"],"prefix":"10.1017","volume":"27","author":[{"given":"R. J.","family":"WYATT","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. F.","family":"GREEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. H.","family":"TUMA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[1997,3,1]]},"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291796004345","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,12]],"date-time":"2019-05-12T19:02:31Z","timestamp":1557687751000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291796004345\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,3]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,3]]}},"alternative-id":["S0033291796004345"],"URL":"https:\/\/doi.org\/10.1017\/s0033291796004345","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,3]]}}}