{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:35:30Z","timestamp":1790854530038,"version":"4.1.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[1997,3,1]],"date-time":"1997-03-01T00:00:00Z","timestamp":857174400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[1997,3]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> Several clinical and neuroimaging \ninvestigations support the notion that underlying brain changes may \nrelate to depression in older patients, especially those with a \nlater-age initial episode. However uncertainty still exists about \ndiagnostic and pathogenic significance of structural brain \nabnormalities in aged depressives, in part because many studies lack \nall-elderly and age-similar normal comparison populations.<\/jats:p><jats:p><jats:bold>Methods.<\/jats:bold> Brain morphology of elderly depressives \n(<jats:italic>N<\/jats:italic> = 30) and normal controls (<jats:italic>N<\/jats:italic> = 36) was compared \nby assessing magnetic resonance imaging (MRI) brain scans with \nqualitative criteria-based scales. Ratings included lateral and third \nventricle enlargement, and cortical, medial temporal, and caudate \natrophy.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> Significant differences between depressed and \ncontrol groups were not demonstrated. Later-onset depressives had \nsignificantly more left medial temporal and left caudate atrophy than \nearly-onset counterparts of similar age. Medial temporal atrophy \nsignificantly correlated with cognitive impairment and was not related \nto physical illness. Depressives with medial temporal atrophy \n(<jats:italic>N<\/jats:italic> = 7) were older and had later age at onset of depression \nthan those without such changes. Cerebrovascular disease risk factors \ndid not predict MRI abnormalities.<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> Results indicate non-specificity and lack of \nhomogeneity of qualitatively measured structural brain changes in \ngeriatric depression, but suggest that pathology of specific, \nlateralized brain regions may be implicated in some later-onset \npatients. The relationship between medial temporal atrophy and \nlate-onset depression raises the possibility that such patients may \nsuffer from as-yet undeclared Alzheimer's disease. Lack of \nassociation between cerebrovascular disease risk factors and brain \nchanges suggests other pathophysiological contributions.<\/jats:p>","DOI":"10.1017\/s0033291796004576","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:36:08Z","timestamp":1027776968000},"page":"421-431","source":"Crossref","is-referenced-by-count":73,"title":["Qualitative magnetic resonance imaging findings in geriatric \ndepression. Possible link between later-onset depression and \nAlzheimer's disease?"],"prefix":"10.1017","volume":"27","author":[{"given":"B. S.","family":"GREENWALD","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"KRAMER-GINSBERG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"BOGERTS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"ASHTARI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"AUPPERLE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"WU","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"ALLEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"ZEMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"PATEL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[1997,3,1]]},"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291796004576","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,12]],"date-time":"2019-05-12T19:02:24Z","timestamp":1557687744000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291796004576\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,3]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,3]]}},"alternative-id":["S0033291796004576"],"URL":"https:\/\/doi.org\/10.1017\/s0033291796004576","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,3]]}}}