{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:18:31Z","timestamp":1791159511828,"version":"4.1.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[1998,7,1]],"date-time":"1998-07-01T00:00:00Z","timestamp":899251200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[1998,7]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> Abnormalities of brain serotonin (5-HT) \ntransmission have been implicated in the \npathophysiology of bulimia nervosa (BN), but no conclusive data have yet\n been provided. The \npurpose of this study was to assess 5-HT transmission via the measurement\n of the prolactin (PRL) \nresponse to the specific 5-HT releasing agent <jats:sc>d<\/jats:sc>-fenfluramine \n(<jats:sc>d<\/jats:sc>-FEN) in both patients with BN and comparison subjects.<\/jats:p><jats:p><jats:bold>Methods.<\/jats:bold> According to a double-blind placebo-controlled \ndesign, plasma PRL response to <jats:sc>d<\/jats:sc>-FEN \nwas measured in 14 drug-free bulimics and 14 matched healthy controls.\n In both patients and \ncontrols, eating-related psychopathology, depressive and obsessive\u2013compulsive\n \nsymptoms, and aggressiveness were measured by rating scales.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> Baseline plasma levels of PRL and 17\u03b2-oestradiol\n \nwere significantly reduced in bulimic \npatients, whereas basal plasma levels of cortisol did not significantly\n \ndiffer from healthy controls. \nPRL response to <jats:sc>d<\/jats:sc>-FEN was not different between patients and \ncontrols as groups, but it was \nsignificantly blunted in bulimics with high frequency bingeing \n([ges     ]2 binge episodes per day; <jats:italic>N<\/jats:italic>=7) \nas compared to both those with low frequency bingeing ([les     ]1 binge \nepisode per day; <jats:italic>N<\/jats:italic>=7) and \nmatched controls. A significant negative correlation emerged between the\n frequency of binge \nepisodes and the hormone response to <jats:sc>d<\/jats:sc>-FEN. Moreover, \nalthough patients scored higher than \nhealthy subjects on rating scales assessing depressive and \nobsessive\u2013compulsive symptoms and \naggressiveness, no significant correlation was found between these measures\n and the PRL response \nto <jats:sc>d<\/jats:sc>-FEN.<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> These results support the idea that serotonin\n \ntransmission is impaired in bulimic \npatients with frequent binge episodes.<\/jats:p>","DOI":"10.1017\/s0033291798006904","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:36:08Z","timestamp":1027776968000},"page":"975-983","source":"Crossref","is-referenced-by-count":26,"title":["Plasma prolactin response to <scp>d<\/scp>-fenfluramine is \nblunted in bulimic patients with frequent binge episodes"],"prefix":"10.1017","volume":"28","author":[{"given":"P.","family":"MONTELEONE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"BRAMBILLA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"BORTOLOTTI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"FERRARO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"MAJ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[1998,7,1]]},"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291798006904","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T19:40:39Z","timestamp":1554320439000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291798006904\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,7]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1998,7]]}},"alternative-id":["S0033291798006904"],"URL":"https:\/\/doi.org\/10.1017\/s0033291798006904","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,7]]}}}