{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T09:38:02Z","timestamp":1770975482767,"version":"3.50.1"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[1998,9,1]],"date-time":"1998-09-01T00:00:00Z","timestamp":904608000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[1998,9]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> There have been no previous studies of the\n outcome \nof different neurotic disorders in \nwhich a prospective group with original randomization to treatment have\n been followed up over a \nlong period. Such studies are important in identifying the factors associated\n with good and poor \noutcome.<\/jats:p><jats:p><jats:bold>Methods.<\/jats:bold> A 5-year follow-up assessment was made of a cohort\n \nof 210 psychiatric out-patients seen \nin general practice psychiatric clinics with a DSM-III diagnosis of \ngeneralized anxiety disorder (71), \npanic disorder (74) or dysthymic disorder (65) and randomized to drug treatment,\n cognitive and \nbehaviour therapy, and self-help. A total of 182 of the patients (87%)\n \nwere assessed after 5 years \nby examination of hospital and GP records using a standardized procedure\n and outcome \ndetermined with a four-point outcome scale.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> One hundred and seven (60%) of the patients had a\n \nfavourable outcome but the remainder \ncontinued to be handicapped either intermittently or continuously throughout\n the 5-year period. \nAnalysis of the value of initial data in predicting outcome using \npolychotomous step-wise logistic \nregression revealed that five variables were significant predictors of\n poor prognosis: older age; \nrecurrent episodes; the presence of personality disorder at entry; general\n neurotic syndrome at \nentry; and symptom severity after 10 weeks. The initial DSM diagnosis and\n original treatment \ngiven, together with ten other variables, were of no predictive value.<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> The long-term outcome of neurotic disorder is\n better \npredicted by age, personality and \nrecency of onset than by other clinical variables with the \nexception of initial response to treatment.<\/jats:p>","DOI":"10.1017\/s0033291798007119","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:33:33Z","timestamp":1027762413000},"page":"1149-1157","source":"Crossref","is-referenced-by-count":71,"title":["Prediction of outcome in neurotic disorder: a 5-year prospective study"],"prefix":"10.1017","volume":"28","author":[{"given":"H.","family":"SEIVEWRIGHT","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"TYRER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"JOHNSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1998,9,1]]},"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291798007119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T21:57:51Z","timestamp":1554933471000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291798007119\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,9]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1998,9]]}},"alternative-id":["S0033291798007119"],"URL":"https:\/\/doi.org\/10.1017\/s0033291798007119","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,9]]}}}