{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T14:05:14Z","timestamp":1763388314779},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[1999,1]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> Benzodiazepines (BZs) can impair explicit\n memory after a single dose and also when \ntaken repeatedly for treatment of anxiety disorders. A previous study with\n agoraphobia\/panic \npatients found that the BZ alprazolam impaired memory during an 8-week\n treatment and residual \nimpairments were still manifest several weeks after drug withdrawal (Curran\n <jats:italic>et al<\/jats:italic>. 1994). The \npresent study followed up the same group of patients 3\u00b75 years after\n treatment to determine whether \nthose memory impairments persisted.<\/jats:p><jats:p><jats:bold>Method.<\/jats:bold> Thirty-one patients, 15 who had originally been treated\n with alprazolam and 16 with \nplacebo, were assessed on a battery of psychometric tests and self-rating\n scales.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> Ex-alprazolam patients performed at the same levels\n as ex-placebo patients on the memory \ntask and on other objective tests. Performance levels of both groups were\n similar to pre-treatment \nbaselines, however there were differences in subjective ratings whereby\n ex-alprazolam patients rated \nthemselves as less attentive and clear headed and more incompetent and\n clumsy than ex-placebo \npatients.<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> Explicit memory impairments found while patients\n were taking alprazolam and weeks \nafter drug withdrawal did not persist 3\u00b75 years later. We suggest\n that the memory impairments \nobserved in our previous study weeks after withdrawal of alprazolam were\n not residual effects of \nalprazolam but rather were due to the drug's interference with practice\n effects on the tests and \nhabituation of anxiety over repeated exposure to the test situation.<\/jats:p>","DOI":"10.1017\/s003329179800734x","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:33:33Z","timestamp":1027762413000},"page":"225-231","source":"Crossref","is-referenced-by-count":27,"title":["Long-term effects of alprazolam on memory: a 3\u00b75 year follow-up\n of \nagoraphobia\/panic patients"],"prefix":"10.1017","volume":"29","author":[{"given":"C.","family":"KILI\u00c7","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. V.","family":"CURRAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"NOSHIRVANI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. M.","family":"MARKS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"BA[Sogon];O\u011eLU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1999,1,1]]},"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S003329179800734X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T16:22:59Z","timestamp":1554740579000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S003329179800734X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,1]]}},"alternative-id":["S003329179800734X"],"URL":"https:\/\/doi.org\/10.1017\/s003329179800734x","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,1]]}}}