{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:56:47Z","timestamp":1778623007828,"version":"3.51.4"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[1999,11,1]],"date-time":"1999-11-01T00:00:00Z","timestamp":941414400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[1999,11]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> Dysthymia is a common mental disorder, associated with considerable disability and \nhigh co-morbidity. This review assessed the role of pharmacological treatment.<\/jats:p><jats:p><jats:bold>Methods.<\/jats:bold> All randomized-controlled trials that compared active drug <jats:italic>versus<\/jats:italic> placebo for dysthymic \npatients were included. Pooled relative risks (RR) and 95% confidence intervals (CI) were \ncalculated with the Random Effect Model method. Where possible, number needed to treat and \nnumber needed to harm were estimated.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> Fifteen trials were included for the main comparisons. Similar results were obtained in \nterms of efficacy for different groups of drugs, such as tricyclic (TCA), selective serotonin reuptake \ninhibitors (SSRI), monoamine oxidase inhibitors (MAOI) and other drugs (sulpiride, amineptine, \nand ritanserin). The pooled RR treatment response was 0\u00b768 (95% CI 0\u00b759\u20130\u00b778) for TCA, 0\u00b764 \n(95% CI 0\u00b755\u20130\u00b774) for SSRIs, 0\u00b759 (95% CI 0\u00b748\u20130\u00b771) for MAOIs. Other drugs (amisulpride, \namineptine and ritanserin) showed similar results. Patients treated on TCA were more likely to \nreport adverse events, compared with placebo. There were no differences in response to active \ntreatment when dysthymia was compared to either dysthymia plus major depression or briefer non-major depressive states.<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> Drug treatment appears to be effective in the short-term management of dysthymic \ndisorder. The choice of drug should take into account specific side-effects profile of each drug.<\/jats:p>","DOI":"10.1017\/s0033291799001324","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:33:33Z","timestamp":1027776813000},"page":"1273-1289","source":"Crossref","is-referenced-by-count":40,"title":["The efficacy of drug treatments for dysthymia: \na systematic review and meta-analysis"],"prefix":"10.1017","volume":"29","author":[{"given":"M. S.","family":"DE LIMA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"HOTOPH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"WESSELY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1999,11,1]]},"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291799001324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T20:01:57Z","timestamp":1557432117000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291799001324\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,11]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1999,11]]}},"alternative-id":["S0033291799001324"],"URL":"https:\/\/doi.org\/10.1017\/s0033291799001324","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,11]]}}}