{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:38:01Z","timestamp":1791016681663,"version":"4.1.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> Serotonergic mechanisms have been proposed for the pathophysiology of seasonal \naffective disorder (SAD) and the therapeutic effect of bright-light treatment. Previously, we showed \nthat SAD patients, in clinical remission with light therapy during the winter, experienced transient \ndepressive relapses after a rapid tryptophan depletion (RTD) technique, which results in decreased \nbrain serotonin levels. The objective of this study was to investigate the effect of RTD in SAD \npatients who were in natural summer remission.<\/jats:p><jats:p><jats:bold>Methods.<\/jats:bold> Twelve drug-free patients with SAD by DSM-IV criteria and 10 normal subjects \nparticipated in this double-blind, placebo-controlled, crossover study. SAD patients were in natural \nsummer remission for at least 8 weeks. Behavioural ratings and plasma tryptophan levels were \nobtained before, and 5 h after, ingesting an amino acid (AA) mixture\u00b1tryptophan. Experimental \nRTD and control sessions were scheduled 1 week apart.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> The RTD session resulted in significant reduction in total and free plasma tryptophan \nlevels compared to the control session. The behavioural data were analysed using repeated measures \nanalysis of variance. This analysis found significant main effects of time (higher scores after AA \ningestion) and diagnosis (higher scores in SAD patients), but no main effect of session or significant \ninteraction effects between the three factors. Thus, there were no significant behavioural effects of \nRTD compared to the sham depletion control session.<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> The summer remission experienced by SAD patients is not dependent on plasma \ntryptophan levels (and presumably brain serotonin function) in the same manner as that of \nremission after light therapy. These results conflict with those of other laboratories, perhaps because \nof differences in study samples.<\/jats:p>","DOI":"10.1017\/s003329179900152x","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:33:33Z","timestamp":1027776813000},"page":"79-87","source":"Crossref","is-referenced-by-count":29,"title":["Effects of rapid tryptophan depletion in patients with \nseasonal affective disorder in natural summer remission"],"prefix":"10.1017","volume":"30","author":[{"given":"R. W.","family":"LAM","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. A.","family":"BOWERING","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. M.","family":"TAM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"GREWAL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. N.","family":"YATHAM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. S.","family":"SHIAH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. P.","family":"ZIS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2000,1,1]]},"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S003329179900152X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T16:22:57Z","timestamp":1567441377000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S003329179900152X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["S003329179900152X"],"URL":"https:\/\/doi.org\/10.1017\/s003329179900152x","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,1]]}}}