{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T16:46:37Z","timestamp":1771001197382,"version":"3.50.1"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2000,3,1]],"date-time":"2000-03-01T00:00:00Z","timestamp":951868800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> Many reports have appeared on associations between platelet monoamine oxidase \n(MAO) activity and susceptibility to psychiatric conditions; principally alcohol dependence but also \nconduct disorder, other drug use and depression. Recently, it has become apparent that MAO \nactivity is inhibited by some component of cigarette smoke, and smokers have low platelet MAO \nactivity. Since the prevalence of smoking is higher in many of the conditions in which MAO has \nbeen implicated, the MAO susceptibility associations may be partly, or entirely, false.<\/jats:p><jats:p><jats:bold>Methods.<\/jats:bold> We have measured platelet MAO in 1551 subjects, recruited from the Australian \nNHMRC Twin Registry, who have provided information on alcohol use and dependence, smoking, \nconduct disorder, depression, attempted suicide, panic disorder and social phobia.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> Current smoking reduced platelet MAO activity in a significant and dose-related manner, \nwith no evidence of lower MAO in ex-smokers or in non-smoking subjects with co-twins who \nsmoked. Alcohol use and lifetime DSM-III-R alcohol dependence history were not associated with \nMAO activity when smoking was taken into account. Depression, panic disorder and social phobia \nshowed no significant associations with platelet MAO activity. Subjects with a history of serious \nattempts at suicide had low platelet MAO activity; but although the difference from controls was \nas great as the reduction associated with smoking it was not significant after correction for smoking \neffects.<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> Although synaptic MAO activity undoubtedly plays a role in psychopathology, the \nconcept that platelet MAO activity is a direct genetic marker of vulnerability to alcohol dependence \ncannot be sustained.<\/jats:p>","DOI":"10.1017\/s0033291799001798","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:33:33Z","timestamp":1027776813000},"page":"443-454","source":"Crossref","is-referenced-by-count":76,"title":["Monoamine oxidase: associations with alcohol \ndependence, smoking and other measures of psychopathology"],"prefix":"10.1017","volume":"30","author":[{"given":"J. B.","family":"WHITFIELD","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"PANG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. K.","family":"BUCHOLZ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. A. F.","family":"MADDEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. C.","family":"HEATH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"STATHAM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. G.","family":"MARTIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2000,3,1]]},"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291799001798","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T16:22:50Z","timestamp":1567441370000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291799001798\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,3]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,3]]}},"alternative-id":["S0033291799001798"],"URL":"https:\/\/doi.org\/10.1017\/s0033291799001798","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,3]]}}}