{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:41:11Z","timestamp":1772754071611,"version":"3.50.1"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2000,10,17]],"date-time":"2000-10-17T00:00:00Z","timestamp":971740800000},"content-version":"unspecified","delay-in-days":46,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2000,9]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> Previous longitudinal studies of the association between depression \nand cognitive dysfunction have had relatively short follow-up periods. This \nreport presents a long-term study of the association between baseline syndromal \ndepression and cognitive outcome measured 9 to 12 years later.<\/jats:p><jats:p><jats:bold>Methods.<\/jats:bold> Self-CARE (D) depression, cognitive function and pre-morbid intelligence \nwere recorded on 1083 subjects on entry to the Medical Research Council trial of \ntreatment of hypertension in older adults in 1983\u20135. In 1994\u20135, we aimed to \nre-interview all survivors to assess cognitive function using the MMSE. We used \nmultivariate analysis to explore whether baseline depression predicted cognitive outcome \nafter this long follow-up period.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> Baseline depression was crudely associated with poorer cognitive outcome \nat time 2. However, this long-term prospective association was no longer apparent \nafter adjusting for baseline cognitive performance, which was associated with baseline \ndepression and robustly predicted cognitive outcome at time 2. We found that gender \nmodified the association between depression and poorer cognitive outcome, so that \nthe association was statistically significant only among men.<\/jats:p><jats:p><jats:bold>Conclusion.<\/jats:bold> Propensity for depression and failing cognition may have common \ndeterminants that still need to be established by future neurobiological \ninvestigations in conjunction with further long-term prospective epidemiological \nresearch.<\/jats:p>","DOI":"10.1017\/s0033291799002779","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:33:33Z","timestamp":1027776813000},"page":"1017-1023","source":"Crossref","is-referenced-by-count":36,"title":["Does depression predict cognitive outcome 9 to 12 years later? Evidence from a prospective study of elderly hypertensives"],"prefix":"10.1017","volume":"30","author":[{"given":"J. A.","family":"CERVILLA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"PRINCE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"JOELS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"MANN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2000,10,17]]},"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291799002779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T19:41:40Z","timestamp":1554320500000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291799002779\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["S0033291799002779"],"URL":"https:\/\/doi.org\/10.1017\/s0033291799002779","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,9]]}}}