{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:07:31Z","timestamp":1783523251250,"version":"3.55.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2001,1,16]],"date-time":"2001-01-16T00:00:00Z","timestamp":979603200000},"content-version":"unspecified","delay-in-days":15,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> Bulimic, impulsive and depressive syndromes have all been associated with \nabnormalities in brain serotonin (5-hydroxytryptamine; 5-HT) mechanisms.<\/jats:p><jats:p><jats:bold>Methods.<\/jats:bold> We had 26 bulimic women and 22 normal-eater women report impulsive, affective, self-destructive \nand bulimic symptoms, and then provide serial blood samples for measurement of: [3H]-paroxetine \nbinding in platelets; and, prolactin (PRL) responses following oral meta-chlorophenyl-piperazine (m-CPP).<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> Bulimic status was associated with markedly reduced density of paroxetine-binding sites, \nmodest blunting of m-CPP stimulated PRL response, and greater nausea following m-CPP. \nBiological variables did not co-vary with most psychopathological or eating-symptom indices. \nHowever, there were inverse associations (in bulimic women only) between scores indicating \nimpulsivity (largely \u2018unreflectiveness\u2019) and density of platelet 5-HT uptake sites.<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> Our observations link bulimia nervosa to altered 5-HT functioning, and suggest that \nthere may be a relatively symptom-specific association between impulsivity and reduced 5-HT\nreuptake.<\/jats:p>","DOI":"10.1017\/s003329179900313x","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:33:33Z","timestamp":1027776813000},"page":"85-95","source":"Crossref","is-referenced-by-count":80,"title":["Implications of impulsive and affective symptoms for serotonin function in bulimia nervosa"],"prefix":"10.1017","volume":"31","author":[{"given":"H.","family":"STEIGER","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. N.","family":"YOUNG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. M. K.","family":"NG YING KIN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"KOERNER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"ISRAEL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"LAGEIX","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"PARIS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2001,1,16]]},"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S003329179900313X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,6]],"date-time":"2019-04-06T20:13:09Z","timestamp":1554581589000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S003329179900313X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,1]]}},"alternative-id":["S003329179900313X"],"URL":"https:\/\/doi.org\/10.1017\/s003329179900313x","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,1]]}}}