{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T22:34:42Z","timestamp":1778366082975,"version":"3.51.4"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[1999,5,1]],"date-time":"1999-05-01T00:00:00Z","timestamp":925516800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychol. Med."],"published-print":{"date-parts":[[1999,5]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold> The hippocampus, amygdala and related functional circuits have been implicated in \nthe regulation of emotional expression and memory processes, which are affected in major \ndepression. Several recent investigations have reported abnormalities in these structures in adult \nand elderly depressives.<\/jats:p><jats:p><jats:bold>Methods.<\/jats:bold> Elderly DSM-III-R unipolar depressives (<jats:italic>N<\/jats:italic>=40) and normal controls (<jats:italic>N<\/jats:italic>=46) \nparticipated in a magnetic resonance imaging study (1.0T). Brain images were obtained in the \ncoronal plane. Using established anatomical guidelines for structure delineation, volumetric \nmeasurements of left and right hippocampus and anterior hippocampus\/amygdala complex were \ncompleted under blinded conditions using a semi-automated computer mensuration system, with \npatients and controls in random order.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold> Medial temporal volumes did not significantly distinguish either elderly depressed and age-similar normal control subjects, or late onset and early onset depressed patients (ANCOVA). Major \noverlap of measured volumes existed between patient and control groups. In depressives, \nhippocampal volumes significantly correlated with age, and cognitive and depression ratings, but \nnot with number of prior depressive episodes or age-at-onset of first depression.<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold> Hippocampal volumes do not discriminate a typical clinical population of elderly \ndepressed patients from age-similar normal control subjects. If hippocampal dysfunction contributes \nto a diagnosis of syndromal depression in the elderly, such dysfunction does not appear to be \nregularly reflected in structural abnormalities captured by volumetric measurement as conducted. \nOn the other hand, relationships between hippocampal volumes and clinical phenomena in \ndepressives, but not controls, suggest potentially meaningful interactions between hippocampal \nstructure and the expression of major depression in the elderly.<\/jats:p>","DOI":"10.1017\/s0033291799008405","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:33:33Z","timestamp":1027776813000},"page":"629-638","source":"Crossref","is-referenced-by-count":119,"title":["Hippocampal\/amygdala volumes in geriatric depression"],"prefix":"10.1017","volume":"29","author":[{"given":"M.","family":"ASHTARI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. S.","family":"GREENWALD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"KRAMER-GINSBERG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"HU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"WU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"PATEL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"AUPPERLE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"POLLACK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1999,5,1]]},"container-title":["Psychological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0033291799008405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T15:28:58Z","timestamp":1554996538000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0033291799008405\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,5]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1999,5]]}},"alternative-id":["S0033291799008405"],"URL":"https:\/\/doi.org\/10.1017\/s0033291799008405","relation":{},"ISSN":["0033-2917","1469-8978"],"issn-type":[{"value":"0033-2917","type":"print"},{"value":"1469-8978","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,5]]}}}