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Despite their sequence and structural diversity, viroporins share a common functional trend: their capacity to assemble transmembrane channels during the replication cycle of the virus. Their selectivity spectrum ranges from low-pH-activated, unidirectional proton transporters, to size-limited permeating pores allowing passive diffusion of metabolites. Through mechanisms not fully understood, expression of viroporins facilitates virion assembly\/release from infected cells, and subverts the cell physiology, contributing to cytopathogenicity. Compounds that interact with viroporins and interfere with their membrane-permeabilizing activity <jats:italic>in vitro<\/jats:italic>, are known to inhibit virus production. Moreover, viroporin-defective viruses comprise a source of live attenuated vaccines that prevent infection by notorious human and livestock pathogens. This review dives into the origin and evolution of the viroporin concept, summarizes some of the methodologies used to characterize the structure\u2013function relationships of these important virulence factors, and attempts to classify them on biophysical grounds attending to their mechanisms of ion\/solute transport across membranes.<\/jats:p>","DOI":"10.1017\/s0033583524000192","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T06:15:03Z","timestamp":1736835303000},"source":"Crossref","is-referenced-by-count":9,"title":["Viroporins: discovery, methods of study, and mechanisms of host-membrane permeabilization"],"prefix":"10.1017","volume":"58","author":[{"given":"Antonio","family":"Alcaraz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6446-5649","authenticated-orcid":false,"given":"Jos\u00e9 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