{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T08:04:34Z","timestamp":1789632274606,"version":"build-2803163510"},"reference-count":11,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"unspecified","delay-in-days":259,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Behav Brain Sci"],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Seth provides a nuanced but compelling case for consciousness being substrate dependent: a product of living processes rather than computation. Here, I offer a biological underpinning for these arguments grounded in the wetware of metabolism in single-celled organisms. Fluctuations in membrane potential give an integrated real-time readout of metabolic state in relation to the environment \u2013 the simplest meaningful \u2018feeling\u2019.<\/jats:p>","DOI":"10.1017\/s0140525x25103658","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:24:21Z","timestamp":1789629861000},"update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["A link between consciousness and the wetware of metabolism"],"prefix":"10.1017","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5433-3973","authenticated-orcid":false,"given":"Nick","family":"Lane","sequence":"first","affiliation":[{"name":"University College London"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"S0140525X25103658_ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2022.1024934"},{"key":"S0140525X25103658_ref12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1404387111"},{"key":"S0140525X25103658_ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s44319-023-00004-6"},{"key":"S0140525X25103658_ref4","volume-title":"Transformer: The deep chemistry of life and death","author":"Lane","year":"2022"},{"key":"S0140525X25103658_ref5","first-page":"13","volume-title":"Origins of mitochondria and hydrogenosomes","author":"Lane","year":"2006"},{"key":"S0140525X25103658_ref3","doi-asserted-by":"publisher","DOI":"10.53765\/20512201.28.9.065"},{"key":"S0140525X25103658_ref6","doi-asserted-by":"publisher","DOI":"10.31234\/osf.io\/pnqw9_v1"},{"key":"S0140525X25103658_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2019.110089"},{"key":"S0140525X25103658_ref10","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2012.3035"},{"key":"S0140525X25103658_ref2","doi-asserted-by":"publisher","DOI":"10.33735\/phimisci.2020.II.64"},{"key":"S0140525X25103658_ref1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1001130"}],"container-title":["Behavioral and Brain Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0140525X25103658","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:24:22Z","timestamp":1789629862000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0140525X25103658\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":11,"alternative-id":["S0140525X25103658"],"URL":"https:\/\/doi.org\/10.1017\/s0140525x25103658","relation":{},"ISSN":["0140-525X","1469-1825"],"issn-type":[{"value":"0140-525X","type":"print"},{"value":"1469-1825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}],"article-number":"e342"}}