{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:07:43Z","timestamp":1786118863485,"version":"build-2736575974"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Anaesthesiology"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1017\/s0265021507002992","type":"journal-article","created":{"date-parts":[[2007,11,22]],"date-time":"2007-11-22T05:10:42Z","timestamp":1195708242000},"page":"211-216","source":"Crossref","is-referenced-by-count":10,"title":["Drotrecogin alfa (activated)"],"prefix":"10.1097","volume":"25","author":[{"given":"S.","family":"Ridley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Lwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Wyncoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Lippett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Gunning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Higgins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-7-20090219","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1056\/NEJM200103083441001","volume":"344","author":"Bernard","year":"2001","journal-title":"N Engl J Med"},{"key":"R3-7-20090219","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1097\/01.CCM.0000181729.46010.83","volume":"33","author":"Vincent","year":"2005","journal-title":"Crit Care Med"},{"key":"R4-7-20090219","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1056\/NEJMoa050935","volume":"353","author":"Abraham","year":"2005","journal-title":"N Engl J Med"},{"key":"R5-7-20090219","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1007\/s00134-005-2829-4","volume":"31","author":"Mackenzie","year":"2006","journal-title":"Intensive Care Med"},{"key":"R6-7-20090219","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/cc3991","volume":"10","author":"Dellinger","year":"2006","journal-title":"Crit Care"},{"key":"R7-7-20090219","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1097\/01.CCM.0000147440.71142.AC","volume":"32","author":"Macias","year":"2004","journal-title":"Crit Care Med"},{"key":"R8-7-20090219","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","volume":"13","author":"Knaus","year":"1985","journal-title":"Crit Care Med"},{"key":"R9-7-20090219","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1097\/01.CCM.0000085141.75513.2B","volume":"31","author":"Padkin","year":"2003","journal-title":"Crit Care Med"},{"key":"R10-7-20090219","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/BF01709751","volume":"22","author":"Vincent","year":"1996","journal-title":"Intensive Care Med"},{"key":"R11-7-20090219","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1365-2044.2004.04068.x","volume":"60","author":"Davies","year":"2005","journal-title":"Anaesthesia"},{"key":"R12-7-20090219","first-page":"CR107","volume":"12","author":"Kubler","year":"2006","journal-title":"Med Sci Morit"},{"key":"R13-7-20090219","first-page":"S62","volume":"31","author":"Vincent","year":"2005","journal-title":"Intensive Care Med"}],"container-title":["European Journal of Anaesthesiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00003643-200803000-00007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T16:54:15Z","timestamp":1786035255000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00003643-200803000-00007"}},"subtitle":["diffusion from clinical trials to clinical practice"],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":12,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1017\/s0265021507002992","relation":{},"ISSN":["0265-0215"],"issn-type":[{"value":"0265-0215","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}