{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:24:11Z","timestamp":1760189051759},"reference-count":71,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,3,10]],"date-time":"2009-03-10T00:00:00Z","timestamp":1236643200000},"content-version":"unspecified","delay-in-days":6918,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Technol Assess Health Care"],"published-print":{"date-parts":[[1990,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The traditional approach to treating dental decay and periodontal disease has often focused on caries, neglecting periodontal infection. The past 15 years have seen significant advances in the treatment of periodontal disease with antimicrobial therapy, both with and without moretraditional debridement or surgery. This article presents an overview of the use of antimicrobials, including an examination of treatment philosophies and the diagnosis of periodontal infection.<\/jats:p>","DOI":"10.1017\/s026646230000101x","type":"journal-article","created":{"date-parts":[[2009,3,10]],"date-time":"2009-03-10T12:06:56Z","timestamp":1236686816000},"page":"403-417","source":"Crossref","is-referenced-by-count":10,"title":["Rationale for the Use of Antimicrobial Agents in Periodontal Disease"],"prefix":"10.1017","volume":"6","author":[{"given":"Walter J.","family":"Loesche","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,3,10]]},"reference":[{"key":"S026646230000101X_ref068","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1979.tb01923.x"},{"key":"S026646230000101X_ref010","first-page":"268","article-title":"Subgingival microbiota associated with puberty: studies of pre-, circum- and postpubertal human females","volume":"8","author":"Delaney","year":"1986","journal-title":"Pediatric Dentistry"},{"key":"S026646230000101X_ref018","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1988.tb01579.x"},{"key":"S026646230000101X_ref003","doi-asserted-by":"publisher","DOI":"10.1177\/00220345870660111301"},{"key":"S026646230000101X_ref030","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1983.tb01297.x"},{"key":"S026646230000101X_ref008","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1982.53.9.557"},{"key":"S026646230000101X_ref067","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.7.5.672"},{"key":"S026646230000101X_ref050","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1988.59.6.366"},{"key":"S026646230000101X_ref055","first-page":"721","article-title":"Induction of lung tumors and malignant lymphomas in mice by metronidazole","volume":"48","author":"Rustia","year":"1972","journal-title":"Journal of the National Cancer Institute"},{"key":"S026646230000101X_ref035","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1128\/MMBR.50.4.353-380.1986","article-title":"Role of Streptococcus mutans in human dental decay","volume":"50","author":"Loesche","year":"1986","journal-title":"Microbiological Reviews"},{"key":"S026646230000101X_ref042","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1984.55.6.325"},{"key":"S026646230000101X_ref069","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1985.56.11s.67"},{"key":"S026646230000101X_ref056","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/63.3.863"},{"key":"S026646230000101X_ref051","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1986.tb01443.x"},{"key":"S026646230000101X_ref028","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(85)90045-7"},{"key":"S026646230000101X_ref046","first-page":"241","article-title":"Multicenter evaluation of tetracycline fiber therapy. 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