{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:34:37Z","timestamp":1760132077775,"version":"3.41.0"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,10,14]],"date-time":"2009-10-14T00:00:00Z","timestamp":1255478400000},"content-version":"unspecified","delay-in-days":6496,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Technol Assess Health Care"],"published-print":{"date-parts":[[1992]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>Based on an American multicenter study, an economic evaluation of prophylactic misoprostol was undertaken in Sweden. The study included 420 patients with osteoarthritis and nonsteroidal anti-inflammatory drug (NSAID)-associated abdominal pain, but no gastric ulcer at inclusion. The frequency of ulcer development with and without prophylactic misoprostol was assessed at 21.7% and 5.6%, respectively, for a 3-month period. All costs for drugs, ambulatory care, hospital care, loss of production, as well as other factors such as dosage and compliance, were transferred to Swedish conditions. It was concluded that in patients with osteoarthritis and NSAID-induced abdominal pain, prophylaxis with misoprostol is cost-effective in Sweden, which is similar to what is found for other countries. A prerequisite for this result is a frequency of ulcer development of 15%. A patient compliance to prophylactic treatment of more than 60% is also presupposed (79% was observed in the above study). Due to the high age of the osteoarthritis patient population, the cost-effectiveness is influenced to only a minor extent by whether indirect costs are included in the calculation.<\/jats:p>","DOI":"10.1017\/s0266462300013465","type":"journal-article","created":{"date-parts":[[2009,10,14]],"date-time":"2009-10-14T15:36:04Z","timestamp":1255534564000},"page":"234-244","source":"Crossref","is-referenced-by-count":29,"title":["Cost-effectiveness of Misoprostol in Sweden"],"prefix":"10.1017","volume":"8","author":[{"given":"Bengt","family":"J\u00f6nsson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Haglund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,10,14]]},"reference":[{"volume-title":"Link\u00f6ping Studies in Arts and Science","year":"1987","author":"Carlsson","key":"S0266462300013465_manual_ref-3"},{"key":"S0266462300013465_manual_ref-9","first-page":"3357","article-title":"Stadig minskning av operationer f\u00f6r ventrikel-och duodenals\u00e5r","volume":"40","author":"Gustavsson","year":"1989","journal-title":"L\u00e4kartidningen"},{"key":"S0266462300013465_manual_ref-13","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.66.778.639"},{"key":"S0266462300013465_manual_ref-10","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1001\/archinte.1989.00390090105021","article-title":"Economic effects of prophylactic use of misoprostol to prevent gastric ulcer in patients taking nonsteroidal anti-inflammatory drugs","volume":"149","author":"Hillman","year":"1989","journal-title":"Archives of Internal Medicine"},{"key":"S0266462300013465_manual_ref-11","first-page":"32","article-title":"Compliance and costs in NSAID therapy","author":"Jacobs","year":"1987","journal-title":"Hosp. Ther."},{"volume-title":"Use of misoprostol as a prophylactic treatment in gastric ulceration associated with nonsteroid anti-inflammatory drugs: An economic evaluation in the French context","year":"1990","author":"de Pouvourville","key":"S0266462300013465_manual_ref-5"},{"key":"S0266462300013465_manual_ref-12","first-page":"22","volume-title":"The value of preventive medicine","author":"J\u00f6nsson","year":"1985"},{"volume-title":"Socioeconomic evaluation of drug therapy","year":"1988","author":"Bloom","key":"S0266462300013465_manual_ref-1"},{"key":"S0266462300013465_manual_ref-15","unstructured":"15. Medical Index Sweden, L\u00e4kemedelsstatistik, 1988."},{"key":"S0266462300013465_manual_ref-17","unstructured":"17. Riksf\u00f6rs\u00e4kringsverket informerar. Den ersatta sjukfr\u00e5nvarons diagnoser 1983. Stockholm: 1987 (statistisk rapport Is-R 1987:5)."},{"volume-title":"An Australian economic analysis of the prevention of NSAID-induced gastric ulceration by misoprostol","year":"1990","author":"Grosse","key":"S0266462300013465_manual_ref-8"},{"key":"S0266462300013465_manual_ref-19","first-page":"159","article-title":"Comparison between medical and elective surgical treatment of peptic ulcers","volume":"155","author":"m","year":"1988","journal-title":"Scandinavian Journal of Gastroenterology"},{"volume-title":"The implications of cost-effectiveness analysis of medical technology","year":"1980","key":"S0266462300013465_manual_ref-16"},{"key":"S0266462300013465_manual_ref-6","unstructured":"6. Gastroskopi-vid utredning av ont i magen. Statens beredning f\u00f6r utv\u00e4rdering av medicinsk teknologi. Stockholm: 1990."},{"key":"S0266462300013465_manual_ref-7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)92892-9"},{"key":"S0266462300013465_manual_ref-14","unstructured":"14. Kostnader per intagen patient, v\u00e5rddag, l\u00e4karbes\u00f6k mm 188. Stockholm: Landstingsf\u00f6r-bundet, 1990."},{"key":"S0266462300013465_manual_ref-20","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198901123200201"},{"volume-title":"DRG i Sverige-Anpassning och registerstudir","year":"1990","key":"S0266462300013465_manual_ref-18"},{"key":"S0266462300013465_manual_ref-4","first-page":"187","article-title":"Economic evaluation of prophylactic treatment with misoprostol in osteoarthritic patients treated with NSAIDs. The case of Belgium","volume":"38","author":"Carrin","year":"1990","journal-title":"Revue d'Epidemi-ologie et de Sant\u00e9 Publique"},{"key":"S0266462300013465_manual_ref-2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/00000658-198307000-00002","article-title":"Ulcer surgery made less expensive","volume":"198","author":"Brodin","year":"1983","journal-title":"Annals of Surgery"}],"container-title":["International Journal of Technology Assessment in Health Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0266462300013465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T22:51:36Z","timestamp":1750459896000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0266462300013465\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1992,1]]}},"alternative-id":["S0266462300013465"],"URL":"https:\/\/doi.org\/10.1017\/s0266462300013465","relation":{},"ISSN":["0266-4623","1471-6348"],"issn-type":[{"type":"print","value":"0266-4623"},{"type":"electronic","value":"1471-6348"}],"subject":[],"published":{"date-parts":[[1992]]}}}