{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T21:44:40Z","timestamp":1649195080638},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,10,14]],"date-time":"2009-10-14T00:00:00Z","timestamp":1255478400000},"content-version":"unspecified","delay-in-days":5765,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Technol Assess Health Care"],"published-print":{"date-parts":[[1994]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although the vaccination initiatives undertaken during the past decade are the cornerstones for protecting the world's children and helping to ensure their survival and development, the vaccines currently being employed may become obstacles for further disease reduction or eradication. Their characteristics complicate or increase the burden on health care infrastructures to maintain or expand vaccine delivery systems. This paper examines an experience with the vaccine technologies that currently are being used by immunization programs in developing countries, illustrating the field problems and obstacles associated with their use. It discusses the advantages and benefits that would accrue if new or improved, heat-stable, multi-antigen vaccines that require only one or two, preferably oral, doses were to become available.<\/jats:p>","DOI":"10.1017\/s0266462300013994","type":"journal-article","created":{"date-parts":[[2009,10,14]],"date-time":"2009-10-14T11:35:22Z","timestamp":1255520122000},"page":"65-70","source":"Crossref","is-referenced-by-count":3,"title":["The Desired Field-Performance Characteristics of New Improved Vaccines for the Developing World"],"prefix":"10.1017","volume":"10","author":[{"given":"Ciro A.","family":"de Quadros","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Carrasco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Marc","family":"Oliv\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,10,14]]},"reference":[{"key":"S0266462300013994_ref009","volume-title":"Monitoring adverse effects following immunization in the Expanded Programme on Immunization","year":"1991"},{"key":"S0266462300013994_ref008","volume-title":"Yellow fever","author":"Strode","year":"1951"},{"key":"S0266462300013994_ref006","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199103000-00011"},{"key":"S0266462300013994_ref005","volume-title":"Reports on cold chain surveys in nine countries of the Americas","year":"1989"},{"key":"S0266462300013994_ref007","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pu.13.050192.001323"},{"key":"S0266462300013994_ref003","volume-title":"Smallpox and its eradication","author":"Fenner","year":"1988"},{"key":"S0266462300013994_ref001","unstructured":"1. Carrasco P. , et al. Poliomyelitis epidemic in indigenous communities of northwestern Peru. In preparation, 1993."},{"key":"S0266462300013994_ref002","unstructured":"2. Clinical efficacy of trivalent oral polio vaccine tested. EPI Newsletter. 1985, 7 (1)."},{"key":"S0266462300013994_ref004","unstructured":"4. Missed opportunities in the Americas: Diagnosis and intervention. EPI Newsletter, 1991, 13 (3)."},{"key":"S0266462300013994_ref010","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199112193252504"}],"container-title":["International Journal of Technology Assessment in Health Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0266462300013994","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T16:22:42Z","timestamp":1557937362000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0266462300013994\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994]]}},"alternative-id":["S0266462300013994"],"URL":"https:\/\/doi.org\/10.1017\/s0266462300013994","relation":{},"ISSN":["0266-4623","1471-6348"],"issn-type":[{"value":"0266-4623","type":"print"},{"value":"1471-6348","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994]]}}}