{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:57:08Z","timestamp":1761101828316},"reference-count":12,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Technol Assess Health Care"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:p><jats:bold>Objectives:<\/jats:bold> The purpose of this study is to describe the situation with the distribution and utilization of prenatal diagnosis technology in China, to identify some important barriers to prenatal diagnosis use, and to suggest changes to improve the present situation.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The study uses cross-sectional surveys to capture quantitative data from both providers and consumers. Qualitative information based on focus group discussions is also presented.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A mail survey of the provincial Bureaus of Health (BOHs) reveals that sixteen provincial prenatal diagnosis centers and twelve city level centers were accredited by the BOHs by July of 2001. These centers were located in thirteen provinces, of thirty in all of China. Of 147 selected institutions surveyed separately, 90.5 ercent offer ultrasound examination, 72.1 percent provide pathogen tests (mainly <jats:italic>Toxoplasma<\/jats:italic>, rubella virus, cytomegalovirus, and herpes simplex or TORCH), 57.1 percent do biochemical tests, 21.8 percent have genetic counseling, 13.6 percent do karyotype testing, 7.5 percent do enzymology testing, and 5.4 percent carry out molecular genetic testing. Chromosome diseases, congenital diseases, and several gene diseases are the target diseases. According to qualitative data, macromanagement for prenatal diagnosis, supplier provision of tests, and population demand are the main influences on prenatal diagnosis use.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> From the quantitative and qualitative analysis, it is clear that the technology of prenatal diagnosis is not diffusing well throughout China and is apparently not appropriately used. The situation of prenatal diagnosis has implications for policy-makers, including identification of priorities, regulation of prenatal diagnosis, strategic planning, development of guidelines based on health technology assessment, and consumer orientation.<\/jats:p>","DOI":"10.1017\/s026646230400145x","type":"journal-article","created":{"date-parts":[[2008,5,6]],"date-time":"2008-05-06T15:38:09Z","timestamp":1210088289000},"page":"524-530","source":"Crossref","is-referenced-by-count":11,"title":["Situation analysis of prenatal diagnosis technology utilization in China: Current situation, main issues, and policy implications"],"prefix":"10.1017","volume":"20","author":[{"given":"Yingyao","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiliu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. David","family":"Banta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangfang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianwen","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianghua","family":"Ying","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2004,11,1]]},"reference":[{"key":"S026646230400145X_ref008","unstructured":"Roemer MI .1991:National health systems of the world.New York:Oxford University Press;31\u201333."},{"key":"S026646230400145X_ref001","doi-asserted-by":"crossref","unstructured":"Bricker L , Garcia J , Henderson J , et al.2000 Ultrasound screening in pregnancy: A systematic review of the clinical effectiveness, cost-effectiveness and women's views.Health Technol Assess. 4:iii\u2013vi.","DOI":"10.3310\/hta4160"},{"key":"S026646230400145X_ref009","unstructured":"WHO.1999.Primary health care approaches for prevention and control of congenital and genetic disorders.Report of a WHO meeting in Cairo"},{"key":"S026646230400145X_ref004","doi-asserted-by":"crossref","unstructured":"Gilbert RE , Augood C , Gupta R , et al.2001 Screening for Down's syndrome: Cost-effectiveness and safety effectiveness.323:423\u2013425.","DOI":"10.1136\/bmj.323.7310.423"},{"key":"S026646230400145X_ref003","unstructured":"Gilbert RE , Augood C , Gupta R , et al.2001 Screening for Down's syndrome: Effects, safety, and cost effectiveness of first and second trimester strategies.BMJ.323:423\u2013425."},{"key":"S026646230400145X_ref011","unstructured":"Yu KM , Wang TF , Zhong HL , et al.2001.Feasibility study of maternal serum screening for Down's syndrome.The 3rd National Prenatal Diagnosis Seminar.Qindao:"},{"key":"S026646230400145X_ref010","doi-asserted-by":"crossref","unstructured":"Woolf S .2001 Accuracy of effectiveness of routine population screening.Int J Technol Assess Health Care. 17:275\u2013304.","DOI":"10.1017\/S0266462301106021"},{"key":"S026646230400145X_ref006","unstructured":"Maternal and child health surveillance of China.Available at: www.wcums.edu.cn\/cmachs\/web-english.html ."},{"key":"S026646230400145X_ref007","unstructured":"Program for birth defect intervention in one city in D province.2001."},{"key":"S026646230400145X_ref002","unstructured":"Center of Statistics and Information, Ministry of Health.Available at: www.moh.gov.cn ."},{"key":"S026646230400145X_ref005","unstructured":"Lin AH , Wu JM , Jiang W , et al.2000 Study on maternal serum screening of AFP and HCG for Down's syndrome.Chin MCH.15:258\u2013259."},{"key":"S026646230400145X_ref012","unstructured":"Zhu LP , Wang HJ , Zhou BH , et al.2000 Current situation of prenatal diagnosis services in Shanghai.Chin J Genet.8:148\u2013149."}],"container-title":["International Journal of Technology Assessment in Health Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S026646230400145X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T19:57:16Z","timestamp":1557172636000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S026646230400145X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["S026646230400145X"],"URL":"https:\/\/doi.org\/10.1017\/s026646230400145x","relation":{},"ISSN":["0266-4623","1471-6348"],"issn-type":[{"value":"0266-4623","type":"print"},{"value":"1471-6348","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11]]}}}