{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T16:05:18Z","timestamp":1765728318811},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2007,1,18]],"date-time":"2007-01-18T00:00:00Z","timestamp":1169078400000},"content-version":"unspecified","delay-in-days":17,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Technol Assess Health Care"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p><jats:bold>Objectives:<\/jats:bold> The cost-effectiveness of prenatal diagnosis intervention for Down's syndrome (DS) in China was assessed and evidence-based information for policy makers and providers is presented.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Based on field surveys in four selected cities in China and a literature review, the economic evaluation of prenatal diagnosis for DS from a societal perspective is conducted by cost-effectiveness analysis.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> In current clinical practice, for a cohort of 10,000 pregnant women, the strategy that delivers karyotyping by chorionic villus sampling (CVS) or amniocentesis (AC) only to those pregnant women 35 years of age and older (maternal age screening strategy) can detect .67 DS births. The strategy that offers the diagnostic test after maternal serum screening with \u03b1-fetoprotein and human chorionic gonadotrophin (maternal serum screening strategy) can detect 1.41 DS births. The cost per prevented DS birth by the maternal age screening strategy and maternal serum screening strategy is US$13,091 and US$56,048, respectively. Sensitivity analysis shows that the maternal serum screening strategy can be cost-effective if uptake rate of CVS or AC for patients with positive serum tests increase while the cost of serum screening decreases.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Although, in general, serum screening has been found to be more cost-effective than maternal age screening, this appears not to be the case in China. The reasons appear to be low uptake rate of the maternal serum strategy, low uptake rate of CVS or AC, and the high price of serum screening. Our findings are that health system factors concerning technology utilization are important determinants of the technology's efficiency.<\/jats:p>","DOI":"10.1017\/s0266462307051689","type":"journal-article","created":{"date-parts":[[2007,1,18]],"date-time":"2007-01-18T20:10:32Z","timestamp":1169151032000},"page":"138-145","source":"Crossref","is-referenced-by-count":13,"title":["Cost-effectiveness analysis of prenatal diagnosis intervention for Down's syndrome in China"],"prefix":"10.1017","volume":"23","author":[{"given":"Yingyao","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart O.","family":"Schweitzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2007,1,18]]},"reference":[{"key":"S0266462307051689_ref020","unstructured":"Tian GL , Cao QX , Zhu WM , Dong QY .2000 Prenatal screening for Down's syndrome and certain fetal defects.Sh J Prev Med.12:212\u2013213."},{"key":"S0266462307051689_ref023","unstructured":"Wen YB , Chen KC , Xiao XF , Li XH .2001 Birth surveillance anal- ysis between 1990-1999 in Shantou City.Dis Surveill.16:782\u2013783."},{"key":"S0266462307051689_ref009","doi-asserted-by":"crossref","unstructured":"Glasson EJ , Sullivan SG , Hussain R , et al.2002 The changing survival profile of people with Down's syndrome: Implications for genetic counseling.Clin Genet.62:390\u2013393.","DOI":"10.1034\/j.1399-0004.2002.620506.x"},{"key":"S0266462307051689_ref017","doi-asserted-by":"crossref","unstructured":"Roizen NJ , Patterson D .2003 Down's syndrome.Lancet.361:1281\u20131289.","DOI":"10.1016\/S0140-6736(03)12987-X"},{"key":"S0266462307051689_ref019","doi-asserted-by":"crossref","unstructured":"Tabor A , Madsen M , Obel EB , et al.1986 Randomized controlled trial of genetic amniocentesis in 4606 low-risk women.Lancet.1:1287\u20131293.","DOI":"10.1016\/S0140-6736(86)91218-3"},{"key":"S0266462307051689_ref015","unstructured":"Liu JT , Hao N , Sun NH , et al.2003 Screening by maternal serum markers for Down's syndrome.Zhongguo Yi Xue Ke Xue Yuan Xue Bao.25:156\u2013159."},{"key":"S0266462307051689_ref026","unstructured":"Yan YL .Prenatal ultrasound diagnosis.1st ed. 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