{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T20:33:39Z","timestamp":1722458019460},"reference-count":32,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T00:00:00Z","timestamp":1531180800000},"content-version":"unspecified","delay-in-days":190,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Technol Assess Health Care"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:sec id=\"S0266462318000247_sec_a1\"><jats:title>Objectives:<\/jats:title><jats:p>Severe hypercholesterolemia is a major cause of death in coronary heart disease. New adjunctive drug therapies have passed authorization processes and been launched recently. So far it is not known which properties of the new treatment options generate the highest benefit for patients. The aim was to evaluate patient priorities in the field of adjunctive drug therapy with apheresis. Therapy characteristics were examined as to their relevance to hypercholesterolemia patients.<\/jats:p><\/jats:sec><jats:sec id=\"S0266462318000247_sec_a2\"><jats:title>Methods:<\/jats:title><jats:p>To identify all potential patient-relevant treatment characteristics, a systematic literature review and ten interviews with patients were conducted. Seven key characteristics were identified from the patient perspective. Patients\u2019 priorities were elicited using an analytic hierarchy process (AHP).<\/jats:p><\/jats:sec><jats:sec id=\"S0266462318000247_sec_a3\"><jats:title>Results:<\/jats:title><jats:p>In total, <jats:italic>N<\/jats:italic> = 61 patients diagnosed with severe hypercholesterolemia and undergoing apheresis participated in the study. The analysis showed predominance for the attribute \u201creduction of LDL-C level in blood\u201d (Wglobal:0.362). The \u201crisk of myopathy\u201d (Wglobal:0.164), \u201crisk of neurocognitive impairment\u201d (Wglobal:0.161) and \u201cfrequency of apheresis\u201d (Wglobal:0.119) were ranked second, third and fourth. Subgroup analyses revealed that \u201cfrequency of apheresis\u201d is of greater importance to younger patients, men and\/or patients who indicated a reduction in quality of life due to apheresis.<\/jats:p><\/jats:sec><jats:sec id=\"S0266462318000247_sec_a4\"><jats:title>Conclusions:<\/jats:title><jats:p>The essential decision criteria for optimal therapy from the patients\u2019 perspective were obtained. \u201cReduction of lipoprotein in blood\u201d was ranked highest compared with the \u201cmode of administration\u201d and \u201cside effects\u201d characteristics. The study offers a transparent approach for the identification of patient priorities for adjunctive PCSK9-inhibitor therapy in apheresis-treated hypercholesterolemia. The project can be used by healthcare decision makers to understand the importance of each patient-relevant endpoint.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0266462318000247","type":"journal-article","created":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T11:13:15Z","timestamp":1531221195000},"page":"267-275","source":"Crossref","is-referenced-by-count":4,"title":["PATIENT PRIORITIES FOR TREATMENT ATTRIBUTES IN ADJUNCTIVE DRUG THERAPY OF SEVERE HYPERCHOLESTEROLEMIA IN GERMANY: AN ANALYTIC HIERARCHY PROCESS"],"prefix":"10.1017","volume":"34","author":[{"given":"Axel C.","family":"M\u00fchlbacher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anika","family":"Kaczynski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz-Werner","family":"Dippel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Bethge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2018,7,10]]},"reference":[{"key":"S0266462318000247_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60771-5"},{"key":"S0266462318000247_ref14","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-4-79"},{"key":"S0266462318000247_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61374-X"},{"key":"S0266462318000247_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2015.12.009"},{"key":"S0266462318000247_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2015.12.003"},{"key":"S0266462318000247_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2016.02.019"},{"key":"S0266462318000247_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv028"},{"key":"S0266462318000247_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s10198-016-0763-8"},{"key":"S0266462318000247_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2015.07.008"},{"key":"S0266462318000247_ref5","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003294"},{"key":"S0266462318000247_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosissup.2012.10.021"},{"key":"S0266462318000247_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2011.03.001"},{"key":"S0266462318000247_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosissup.2014.07.006"},{"key":"S0266462318000247_ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1501031"},{"key":"S0266462318000247_ref21","volume-title":"The analytic hierarchy process. 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