{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T17:53:58Z","timestamp":1759514038331,"version":"3.40.5"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T00:00:00Z","timestamp":1575331200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Technol Assess Health Care"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Formularies are used by payers to optimize access and ensure the appropriate use of medications. Lack of follow-up and re-evaluation can lead to outdated formularies that are not reflective of current evidence. Formulary modernization, an approach to re-align formularies with current evidence has proven successful. The Ontario Drug Policy Research Network (ODPRN) launched a framework for conducting comprehensive drug-class reviews. This commentary describes the individual components of this framework and lessons learned through completion of 12 reviews between 2013 and 2016. We present the ODPRN drug-class review of treatments for chronic hepatitis B as a case example to illustrate the components and impact. The incorporation of foundational health technology assessment components such as economic evaluations and knowledge synthesis with contextualizing evidence such as patient and clinician perspectives (through qualitative studies), real-world evidence (through data analytics), and cross-jurisdictional comparisons (through environmental scans and data analytics), successfully developed jurisdictionally specific policy recommendations grounded in up-to-date evidence. The ODPRN framework for conducting comprehensive drug-class reviews is a robust and feasible approach to conduct formulary modernization. This framework allows for actionable and specific policies which are likely to be considered by decision makers. Adoption of similar frameworks in other jurisdictions may improve uptake of evidence-informed policy recommendations.<\/jats:p>","DOI":"10.1017\/s0266462319000746","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T11:42:34Z","timestamp":1575373354000},"page":"12-19","source":"Crossref","is-referenced-by-count":5,"title":["Comprehensive Drug-Class Review Framework for improved evidence-based drug policy and formulary modernization"],"prefix":"10.1017","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1911-6129","authenticated-orcid":false,"given":"Mina","family":"Tadrous","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Knowles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent","family":"Ruddock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad M.","family":"Mamdani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David N.","family":"Juurlink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2019,12,3]]},"reference":[{"key":"S0266462319000746_ref18","first-page":"A22","article-title":"Estimation of immigration related CHB infection and hepatocellular carcinoma development in Canada from 1981\u20132006","author":"Leber","year":"2009","journal-title":"Can J Gastroenterol"},{"key":"S0266462319000746_ref14","first-page":"715","article-title":"The management of chronic viral hepatitis: A Canadian consensus conference","volume":"18","author":"Sherman","year":"2004","journal-title":"Can J Gastroenterol Hepatol"},{"key":"S0266462319000746_ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0465-6"},{"key":"S0266462319000746_ref7","unstructured":"Ontario Drug Policy Research Network (2015) Treatment of CHB in Ontario. Available at: http:\/\/odprn.ca\/research\/drug-class-review\/chronic-hepatitis-b\/. Accessed December 1, 2018."},{"key":"S0266462319000746_ref4","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.070713"},{"key":"S0266462319000746_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.02.010"},{"key":"S0266462319000746_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.healthpol.2014.06.007"},{"key":"S0266462319000746_ref1","unstructured":"Canadian Institute for Health Information (2016) Prescribed drug spending in Canada, 2016: A focus on public drug programs. Available at: https:\/\/secure.cihi.ca\/free_products\/Prescribed%20Drug%20Spending%20in%20Canada_2016_EN_web.pdf. Accessed December 1, 2018."},{"key":"S0266462319000746_ref5","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-12-140"},{"key":"S0266462319000746_ref13","first-page":"345","article-title":"Epidemiology of hepatitis B in Canada","volume":"12","author":"Zhang","year":"2001","journal-title":"Can J Infect Dis Med Microbiol"},{"key":"S0266462319000746_ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-012-9365-4"},{"volume-title":"Principles of a sound drug formulary system","year":"2000","author":"Pharmacopeia","key":"S0266462319000746_ref3"},{"key":"S0266462319000746_ref17","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28156"},{"key":"S0266462319000746_ref9","doi-asserted-by":"publisher","DOI":"10.1111\/head.12585"},{"key":"S0266462319000746_ref2","doi-asserted-by":"publisher","DOI":"10.1377\/hlthaff.25.2.337"},{"key":"S0266462319000746_ref19","first-page":"464","article-title":"Publicly funded oral CHB treatment patterns in Ontario over 16 years: An ecologic study","volume":"24","author":"Tadrous","year":"2018","journal-title":"J Manag Care Spec Pharm"},{"key":"S0266462319000746_ref20","unstructured":"Ministry of Health and Long-Term Care Ontario Public Drug Programs (2018) Notice from the executive officer: Funding of hepatitis B drugs under the Ontario Drug Benefit Program. Available at: http:\/\/www.health.gov.on.ca\/en\/pro\/programs\/drugs\/opdp_eo\/notices\/exec_office_20180221.pdf. Accessed December 1, 2018."},{"key":"S0266462319000746_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)61412-X"},{"key":"S0266462319000746_ref10","unstructured":"Kwong, J , Crowcroft, N , Campitelli, M , (2010) Ontario Burden of Infectious Disease Study Advisory Group; Ontario Burden of Infectious Disease Study (ONBOIDS): An OAHPP\/ICES Report. Toronto: Ontario Agency for Health Protection and Promotion. Institute for Clinical Evaluative Sciences, 28\u201333."},{"key":"S0266462319000746_ref11","first-page":"351","article-title":"CHB in Canada","volume":"12","author":"Minuk","year":"2001","journal-title":"Can J Infect Dis Med Microbiol"}],"container-title":["International Journal of Technology Assessment in Health Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0266462319000746","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T10:52:04Z","timestamp":1585651924000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0266462319000746\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,3]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020]]}},"alternative-id":["S0266462319000746"],"URL":"https:\/\/doi.org\/10.1017\/s0266462319000746","relation":{},"ISSN":["0266-4623","1471-6348"],"issn-type":[{"type":"print","value":"0266-4623"},{"type":"electronic","value":"1471-6348"}],"subject":[],"published":{"date-parts":[[2019,12,3]]}}}