{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:57:14Z","timestamp":1747173434272,"version":"3.40.5"},"reference-count":49,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"unspecified","delay-in-days":82,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"funder":[{"name":"Italian Ministry of Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Technol Assess Health Care"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S0266462321001720_sec1\">\n\t    <jats:title>Objectives<\/jats:title>\n\t    <jats:p>Scientific literature debates on the economic affordability of transcatheter aortic valve implantation (TAVI) in order to give a useful support to decision makers aiming at establishing a reimbursement scheme for TAVI. For this reason, it is important to assess the quality and the generalizability of the existing economic evidences.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0266462321001720_sec2\" sec-type=\"methods\">\n\t    <jats:title>Methods<\/jats:title>\n\t    <jats:p>The first step was to run a literature search according to a predefined population, intervention, comparator, and outcome on the cost and effectiveness of the TAVI procedure in comparison to medical therapy and traditional surgery. Second, a manual search was carried out on the Web sites of the main HTA agencies. Third, the checklist developed by Augustovski et al. was applied in order to assess the quality and the generalizability of the articles resulting from the selection process.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0266462321001720_sec3\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>Overall, 106 articles were obtained. Of these, sixty-five articles were excluded since the title was not consistent with the objective. Further selection took place after abstract and full-text reading. In the end, thirty-one documents were included for the review. According to the checklist, none of the articles was considered generalizable and only one was considered transferable which compares the TAVI procedure with Medical Management in inoperable patients.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0266462321001720_sec4\" sec-type=\"conclusions\">\n\t    <jats:title>Conclusions<\/jats:title>\n\t    <jats:p>Despite the overall quality of the selected studies was considered good, there is still a lack of evidence on whether evidences generated in different contexts can be considered generalizable. Further research on resource consumption and preferences is needed in order to provide decision makers with more robust evidences.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/s0266462321001720","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T03:59:36Z","timestamp":1648180776000},"source":"Crossref","is-referenced-by-count":0,"title":["The transcatheter aortic valve implantation: an assessment of the generalizability of the economic evidences following a systematic review"],"prefix":"10.1017","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5703-7424","authenticated-orcid":false,"given":"Matteo","family":"Ruggeri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandolini","family":"Donatella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Campisi","family":"Federica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danese","family":"Salvatore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santori","family":"Costanza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiappetta","family":"Marta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roazzi","family":"Paolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marchetti","family":"Marco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2022,3,24]]},"reference":[{"key":"S0266462321001720_r1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/imj.14071","article-title":"Contemporary review of severe aortic stenosis","volume":"49","author":"Adams","year":"2019","journal-title":"Intern Med J."},{"unstructured":"49. Health Information and Quality Authority. Health technology assessment of transcatheter aortic valve implantation (TAVI) in patients with severe symptomatic aortic stenosis at low and intermediate risk of surgical complications. November 2019.","key":"S0266462321001720_r49"},{"key":"S0266462321001720_r37","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.ijcard.2014.12.109","article-title":") Transfemoral transcatheter aortic valve replacement compared with surgical replacement in patients with severe aortic stenosis and comparable risk: Cost-utility and its determinants","volume":"182","author":"Ribera","year":"2015","journal-title":"Int J Cardiol."},{"key":"S0266462321001720_r15","first-page":"1","article-title":"Transcatheter aortic valve implantation (TAVI) for treatment of aortic valve stenosis","volume":"12","author":"Sehatzadeh","year":"2012","journal-title":"Ont Health Technol Assess Ser"},{"key":"S0266462321001720_r36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta17330","article-title":") Cost-effectiveness of transcatheter aortic valve implantation (TAVI) for aortic stenosis in patients who are high risk or contraindicated for surgery: A model-based economic evaluation","volume":"17","author":"Orlando","year":"2013","journal-title":"Health Technol Assess."},{"unstructured":"47. Belgian Health Care Knowledge Centre. Transcatheter aortic valve implantation (TAVI): A health technology assessment update. 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Health Quality Ontario (2016) Transcatheter aortic valve implantation for treatment of aortic valve stenosis: A health technology assessment.","key":"S0266462321001720_r3"},{"key":"S0266462321001720_r24","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1161\/CIRCOUTCOMES.113.000280","article-title":"Transcatheter aortic valve replacement in nonsurgical candidates with severe, symptomatic aortic stenosis: A cost-effectiveness analysis","volume":"6","author":"Simons","year":"2013","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"S0266462321001720_r21","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1161\/CIRCULATIONAHA.118.035236","article-title":"Cost-effectiveness of transcatheter vs. surgical aortic valve replacement in patients with severe aortic stenosis at intermediate risk: Results from the PARTNER 2 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effectiveness of transcatheter aortic valve omplantation","volume":"32","author":"Kularatna","year":"2016","journal-title":"Int J Technol Assess Health Care"},{"key":"S0266462321001720_r32","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jacc.2015.10.046","article-title":"Cost-effectiveness of transcatheter aortic valve replacement with a self-expanding prosthesis versus surgical aortic valve replacement","volume":"67","author":"Reynolds","year":"2016","journal-title":"J Am Coll Cardiol."},{"key":"S0266462321001720_r48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta17330","article-title":"Cost-effectivness of trancatheter aortic valve impantation (TAVI) for aortic stenosis in patients who are high risk or contraindicated for surgery: A model-based economic evaluation","volume":"17","author":"Orlando","year":"2013","journal-title":"Health Technol Assess."},{"key":"S0266462321001720_r8","first-page":"1","article-title":") Transcatheter aortic valve 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