{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T16:09:36Z","timestamp":1748275776541,"version":"3.37.3"},"reference-count":36,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"unspecified","delay-in-days":16,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"funder":[{"DOI":"10.13039\/501100002001","name":"Health Services and Delivery Research Programme","doi-asserted-by":"publisher","award":["RP-PG1212-20015"],"award-info":[{"award-number":["RP-PG1212-20015"]}],"id":[{"id":"10.13039\/501100002001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Technol Assess Health Care"],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S0266462322003373_sec1\">\n\t    <jats:title>Background<\/jats:title>\n\t    <jats:p>Adherence to preventative inhaled therapies in people with cystic fibrosis (CF) is low, resulting in potentially avoidable health losses and the need for costly rescue therapies.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0266462322003373_sec2\">\n\t    <jats:title>Objectives<\/jats:title>\n\t    <jats:p>To estimate the cost-effectiveness of the CFHealthHub (CFHH) intervention to support adherence to inhaled medications.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0266462322003373_sec3\" sec-type=\"methods\">\n\t    <jats:title>Methods<\/jats:title>\n\t    <jats:p>A state transition model was developed to assess the cost-effectiveness of the CFHH intervention versus usual care from the perspective of the UK National Health Service and Personal Social Services over a lifetime horizon. Costs and health outcomes were discounted at a rate of 3.5 percent per annum. Costs were valued at 2021\/22 prices. The model structure includes health states defined by survival status, level of lung function, and transplant history. Treatment effects were modeled by changing the probabilities of transitioning between lung function states and reducing exacerbation rates. Model parameters were informed by the CFHH trial, CF Registry data, routine cost databases, literature, and expert opinion. Deterministic and probabilistic sensitivity analyses were undertaken to assess uncertainty.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0266462322003373_sec4\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>The CFHH intervention is expected to generate additional health gains and cost savings compared with usual care. Assuming that it is delivered for 10\u00a0years, the CFHH intervention is expected to generate 0.17 additional quality-adjusted life years and cost savings of GBP 1,600 (EUR 1,662) per patient.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0266462322003373_sec5\" sec-type=\"conclusions\">\n\t    <jats:title>Conclusions<\/jats:title>\n\t    <jats:p>The CFHH intervention is expected to dominate usual care, irrespective of the duration over which the intervention is delivered. The modeled benefits and cost savings are smaller than initially expected and are sensitive to relative treatment effects on lung function.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/s0266462322003373","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T08:43:57Z","timestamp":1673945037000},"source":"Crossref","is-referenced-by-count":1,"title":["A model-based economic analysis of the CFHealthHub intervention to support adherence to inhaled medications for people with cystic fibrosis in the UK"],"prefix":"10.1017","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6612-2332","authenticated-orcid":false,"given":"Paul","family":"Tappenden","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline","family":"Navega Biz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nica","family":"Hern\u00e1ndez Alava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Sasso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Sutton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Ennis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Wildman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2023,1,17]]},"reference":[{"key":"S0266462322003373_r2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39391.713229.AD"},{"key":"S0266462322003373_r3","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.10127"},{"key":"S0266462322003373_r27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2012.02.008"},{"key":"S0266462322003373_r9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2011.03.005"},{"key":"S0266462322003373_r10","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-11-5"},{"key":"S0266462322003373_r11","first-page":"1","volume-title":"Programme grants for applied research","author":"Wildman","year":"2021"},{"volume-title":"ACtiF trial data [data held on file]","year":"2019","author":"Wildman","key":"S0266462322003373_r16"},{"volume-title":"British National Formulary (online)","year":"2022","key":"S0266462322003373_r22"},{"volume-title":"CF registry bespoke dataset (years 2006\u20132015; 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