{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:28:22Z","timestamp":1778660902950,"version":"3.51.4"},"reference-count":44,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"unspecified","delay-in-days":122,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Technol Assess Health Care"],"published-print":{"date-parts":[[2024]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:sec id=\"S0266462324000242_sec1\">\n\t    <jats:title>Objectives<\/jats:title>\n\t    <jats:p>While patient input to health technology assessment (HTA) has traditionally been of a qualitative nature, there is increasing interest to integrate quantitative evidence from patient preference studies into HTA decision making. Preference data can be used to generate disease-specific health utility data. We generated a health utility score for patients with chronic obstructive pulmonary disease (COPD) and consider its use within HTAs.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0266462324000242_sec2\" sec-type=\"methods\">\n\t    <jats:title>Methods<\/jats:title>\n\t    <jats:p>Based on qualitative research, six symptoms were identified as important to COPD patients: shortness of breath, exacerbations, chronic cough, mucus secretion, sleep disturbance, and urinary incontinence. We employed a discrete choice experiment (DCE) and the random parameter logistic regression technique to estimate utility scores for all COPD health states. The relationship between patients\u2019 COPD health utility scores, self-perceived COPD severity, and EQ-5D-3L utility scores was analyzed, with data stratified according to disease severity and comorbidity subgroups.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0266462324000242_sec3\" sec-type=\"results\">\n\t    <jats:title>Results<\/jats:title>\n\t    <jats:p>The COPD health utility score had face validity, with utility scores negatively correlated with patients\u2019 self-perceived COPD severity. The correlation between the COPD health utility scores and EQ-5D-3L values was only moderate. While patient EQ-5D-3L scores were impacted by comorbidities, the COPD health utility score was less impacted by comorbid conditions.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0266462324000242_sec4\" sec-type=\"conclusions\">\n\t    <jats:title>Conclusions<\/jats:title>\n\t    <jats:p>Our COPD utility measure, derived from a DCE, provides a patient-centered health utility score and is more sensitive to the COPD health of the individual and less sensitive to other comorbidities. This disease-specific instrument should be considered alongside generic health-related quality of life instruments when valuing new COPD therapies in submissions to licensing and reimbursement agencies.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/s0266462324000242","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T08:28:18Z","timestamp":1714638498000},"source":"Crossref","is-referenced-by-count":3,"title":["Development of a disease-specific health utility score for chronic obstructive pulmonary disease from a discrete choice experiment patient preference study"],"prefix":"10.1017","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0240-2906","authenticated-orcid":false,"given":"Byron","family":"Jones","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandy","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8211-7613","authenticated-orcid":false,"given":"Nigel S.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian S.","family":"Gutzwiller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2024,5,2]]},"reference":[{"key":"S0266462324000242_r28","doi-asserted-by":"publisher","DOI":"10.1177\/002224379403100408"},{"key":"S0266462324000242_r12","doi-asserted-by":"publisher","DOI":"10.1186\/s13561-016-0108-4"},{"key":"S0266462324000242_r16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61729-2"},{"key":"S0266462324000242_r42","doi-asserted-by":"publisher","DOI":"10.1007\/s40271-021-00521-3"},{"key":"S0266462324000242_r17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61728-0"},{"key":"S0266462324000242_r5","doi-asserted-by":"publisher","DOI":"10.1111\/hex.12594"},{"key":"S0266462324000242_r20","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)07492-2"},{"key":"S0266462324000242_r18","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00025805"},{"key":"S0266462324000242_r19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030442"},{"key":"S0266462324000242_r3","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2019.00082"},{"key":"S0266462324000242_r7","doi-asserted-by":"publisher","DOI":"10.1186\/s40900-016-0018-y"},{"key":"S0266462324000242_r2","doi-asserted-by":"publisher","DOI":"10.1007\/s40271-017-0249-5"},{"key":"S0266462324000242_r10","doi-asserted-by":"publisher","DOI":"10.1007\/s40271-019-00408-4"},{"key":"S0266462324000242_r38","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.914338"},{"key":"S0266462324000242_r23","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.01.012"},{"key":"S0266462324000242_r36","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1050(200003)9:2<127::AID-HEC500>3.0.CO;2-Y"},{"key":"S0266462324000242_r40","volume-title":"Health related quality of life aspects not captured by EQ-5D-5L: results from the IMPRESS (international multiple sclerosis) study","author":"Mossman","year":"2016"},{"key":"S0266462324000242_r1","doi-asserted-by":"publisher","DOI":"10.1007\/s40271-018-0325-5"},{"key":"S0266462324000242_r41","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-017-0591-2"},{"key":"S0266462324000242_r8","doi-asserted-by":"publisher","DOI":"10.1007\/s40271-018-0305-9"},{"key":"S0266462324000242_r21","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2015.36.3812"},{"key":"S0266462324000242_r44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0197434"},{"key":"S0266462324000242_r31","doi-asserted-by":"publisher","DOI":"10.1017\/S0266462309090059"},{"key":"S0266462324000242_r32","doi-asserted-by":"publisher","DOI":"10.1017\/S0266462313000640"},{"key":"S0266462324000242_r26","first-page":"00128","article-title":"Patients\u2019 perspectives on COPD: findings from a social media listening study","volume":"5","author":"Cook","year":"2019","journal-title":"Eur Respir Soc"},{"key":"S0266462324000242_r43","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-6773.2008.00860.x"},{"key":"S0266462324000242_r13","doi-asserted-by":"publisher","DOI":"10.3109\/07853890109002087"},{"key":"S0266462324000242_r30","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v095.i11"},{"key":"S0266462324000242_r34","doi-asserted-by":"publisher","DOI":"10.1007\/s40271-018-0329-1"},{"key":"S0266462324000242_r22","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-2933"},{"key":"S0266462324000242_r14","unstructured":"14. 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