{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:43:47Z","timestamp":1793231027525,"version":"4.5.0"},"reference-count":54,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"unspecified","delay-in-days":331,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100018694","name":"HORIZON EUROPE Marie Sklodowska-Curie Actions","doi-asserted-by":"publisher","award":["823995"],"award-info":[{"award-number":["823995"]}],"id":[{"id":"10.13039\/100018694","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Technol Assess Health Care"],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0266462325103279_sec1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite omics technologies gaining traction in clinical settings, particularly in oncology, challenges persist in their widespread adoption due to the pre-requisite robust evidence supporting efficacy and cost-effectiveness. This study aims to explore the experiences of organizations working in the health technology assessment (HTA) field in evaluating omics technologies, with a particular focus on the adoption and application of specific assessment frameworks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0266462325103279_sec2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a global survey to gather insights into current practices and frameworks used in HTA evaluations of omics technologies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0266462325103279_sec3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We gathered responses from thirty-nine participants representing organizations across twenty-nine countries and five continents. Among them, 51 percent (n\u00a0=\u00a020) reported experience in evaluating omics technologies, including multi-omics tests for early disease detection, biomarker-based cancer diagnostics, and advanced genomic sequencing techniques. Only three organizations employed specific assessment frameworks: the\n                      <jats:italic>Adelaide Health Technology Assessment Agency<\/jats:italic>\n                      in Australia, the\n                      <jats:italic>Netherlands Cancer Institute<\/jats:italic>\n                      , and the\n                      <jats:italic>Andalusian HTA Agency<\/jats:italic>\n                      in Spain. These frameworks address key evaluation aspects such as analytical and clinical validity, clinical and personal utility, organizational impact, and ethical, legal, and social implications of omics technologies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0266462325103279_sec4\" sec-type=\"discussion\">\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Despite their relevance, the limited adoption of tailored frameworks highlights the need for more structured and context-specific approaches to facilitate the integration of omics technologies into healthcare systems. Collaborative efforts among stakeholders, including patients, healthcare providers, policymakers, and industry representatives, are crucial for devising robust evaluation strategies addressing the complexities of omics technologies comprehensively.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0266462325103279","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T11:13:52Z","timestamp":1764328432000},"source":"Crossref","is-referenced-by-count":5,"title":["Value-based health care frameworks for the health technology assessments of \u201comics\u201d technologies: an international survey"],"prefix":"10.1017","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1029-9539","authenticated-orcid":false,"given":"Tommaso","family":"Osti","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03h7r5v07","id-type":"ROR","asserted-by":"publisher"}],"name":"Universita Cattolica del Sacro Cuore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelrahman","family":"Taha","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03h7r5v07","id-type":"ROR","asserted-by":"publisher"}],"name":"Universita Cattolica del Sacro Cuore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0420-8816","authenticated-orcid":false,"given":"Eva","family":"Reviriego-Rodrigo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/054hj6489","id-type":"ROR","asserted-by":"publisher"}],"name":"Basque Foundation for Health Innovation and Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Pastorino","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03h7r5v07","id-type":"ROR","asserted-by":"publisher"}],"name":"Universita Cattolica del Sacro Cuore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Boccia","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03h7r5v07","id-type":"ROR","asserted-by":"publisher"}],"name":"Universita Cattolica del Sacro Cuore"},{"id":[{"id":"https:\/\/ror.org\/00rg70c39","id-type":"ROR","asserted-by":"publisher"}],"name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4080-7963","authenticated-orcid":false,"given":"I\u00f1aki","family":"Gutierrez-Ibarluzea","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/054hj6489","id-type":"ROR","asserted-by":"publisher"}],"name":"Basque Foundation for Health Innovation and Research"},{"id":[{"id":"https:\/\/ror.org\/00pz2fp31","id-type":"ROR","asserted-by":"publisher"}],"name":"Ministry for Health, Basque Government"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"S0266462325103279_r38","doi-asserted-by":"publisher","DOI":"10.52766\/TNOL4288"},{"key":"S0266462325103279_r1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00391-2017"},{"key":"S0266462325103279_r39","unstructured":"39. 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