{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T04:38:48Z","timestamp":1767847128163,"version":"3.49.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Technol Assess Health Care"],"published-print":{"date-parts":[[1999,1]]},"abstract":"<jats:p>This paper examines the current status of in vitro fertilization and embryo \ntransfer (IVF-ET) as a treatment for various types of infertility. We reviewed \nstudies on the efficacy and safety of IVF-ET and intracytoplasmic sperm \ninjection (ICSI) plus IVF-ET, compared with conventional treatment or no \ntreatment for various infertility diagnoses. Material retrieved included \nEnglish language publications between 1992 and January 1997 that reported the \nresults of prospective controlled clinical trials, cohort studies, and \nretrospective comparative studies with large series, and reviews presenting \nrisks, complications, and longer-term health consequences associated with \nIVF-ET and ICSI. No adequate prospective comparative studies of sufficient \npower on the use of IVF-ET for specific infertility diagnoses have been \nreported to date. Most of the published reports concerning results with IVF-ET \nas a treatment of infertility have been based upon small, uncontrolled \nstudies, with various methodological weaknesses. Reported results are not \ndirectly comparable. There are few follow-up data on outcomes after pregnancy \nis established or on long-term health consequences of the use of IVF-ET on \nmothers and their babies. IVF-ET has diffused widely without comprehensive \nassessment of its efficacy and safety. The available evidence supports its use \nonly for severe bilateral tubal occlusion. For other diagnoses of infertility \nthe evidence is limited and does not establish whether IVF-ET is effective. \nLong-term, well-designed, prospective clinical trials are required to \ndetermine when and for what indications IVF-ET is effective and what its \nhealth effects are on both mothers and their babies.<\/jats:p>","DOI":"10.1017\/s0266462399015172","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:39:16Z","timestamp":1027777156000},"page":"66-85","source":"Crossref","is-referenced-by-count":8,"title":["THE EFFICACY AND ADVERSE EFFECTS OF IN VITRO FERTILIZATION AND EMBRYO \nTRANSFER"],"prefix":"10.1017","volume":"15","author":[{"given":"Paula","family":"Corabian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Hailey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[1999,1,1]]},"container-title":["International Journal of Technology Assessment in Health Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0266462399015172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T19:21:27Z","timestamp":1557516087000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0266462399015172\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,1]]}},"alternative-id":["S0266462399015172"],"URL":"https:\/\/doi.org\/10.1017\/s0266462399015172","relation":{},"ISSN":["0266-4623","1471-6348"],"issn-type":[{"value":"0266-4623","type":"print"},{"value":"1471-6348","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,1]]}}}