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The paper imposes a weak nonparametric restriction on the form of the conditional means and maintains a single-index assumption on the distribution of the dependent variable in the equation of interest. The estimation method follows a two-step approach: The first step estimates the conditional means in the index nonparametrically, and the second step estimates the parameters by an analytically convenient weighted average derivative method. It is established that the two-step estimator is root-<jats:italic>n<\/jats:italic>-consistent and asymptotically normal. 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