{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T15:07:29Z","timestamp":1767625649652},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"S1","license":[{"start":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:00:00Z","timestamp":1417478400000},"content-version":"unspecified","delay-in-days":4963,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2001,5]]},"abstract":"<jats:p>Genetic and nongenetic factors have been identified to have roles in the etiology of dementia. Etiologic heterogeneity and genetic heterogeneity are recognized, especially for Alzheimer\u2019s disease which is the most common form of dementia. Asymptomatic individuals are increasingly requesting genetic services such as genetic counselling, predictive testing and screening for genetic risk factors. This paper provides an overview of the current knowledge about genetic counselling and genetic screening for dementia as well as guidelines for the physician.<\/jats:p>","DOI":"10.1017\/s0317167100001207","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T15:38:34Z","timestamp":1418398714000},"page":"S52-S55","source":"Crossref","is-referenced-by-count":3,"title":["Genetic Counselling and Genetic Screening for Alzheimer\u2019s Disease and Other Dementias"],"prefix":"10.1017","volume":"28","author":[{"given":"A. Dessa","family":"Sadovnick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,12,2]]},"reference":[{"key":"S0317167100001207_ref014","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960601)77:11<2318::AID-CNCR21>3.0.CO;2-Z"},{"key":"S0317167100001207_ref008","first-page":"361","article-title":"Association of early-onset Alzheimer\u2019s disease with an interleukin-1 \u03b1 gene polymorphism","volume":"47","author":"Grimaldi","year":"2000","journal-title":"Neurology"},{"key":"S0317167100001207_ref005","doi-asserted-by":"publisher","DOI":"10.1126\/science.8346443"},{"key":"S0317167100001207_ref006","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.8.1467"},{"key":"S0317167100001207_ref022","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380103"},{"key":"S0317167100001207_ref027","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540340066035"},{"key":"S0317167100001207_ref013","first-page":"636","article-title":"Genetic counselling","volume":"26","author":"Fraser","year":"1974","journal-title":"Am J Hum Genet"},{"key":"S0317167100001207_ref016","doi-asserted-by":"publisher","DOI":"10.1086\/301707"},{"key":"S0317167100001207_ref001","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.1.66"},{"key":"S0317167100001207_ref018","first-page":"48","article-title":"Genomic screen of 739 sibpairs with late-onset Alzheimer\u2019s disease","volume":"67","author":"Pericak-Vance","year":"2000","journal-title":"Am J Hum Genet"},{"key":"S0317167100001207_ref009","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200003)47:3<365::AID-ANA13>3.0.CO;2-G"},{"key":"S0317167100001207_ref017","first-page":"619","article-title":"Chromosome 14 and late-onset familial Alzheimer\u2019s disease (FAD)","volume":"53","author":"Schellenberg","year":"1994","journal-title":"Am J Hum Genet"},{"key":"S0317167100001207_ref020","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.7.857"},{"key":"S0317167100001207_ref025","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.1.139"},{"key":"S0317167100001207_ref031","volume-title":"Evidence-Based Dementia: A Practical Guide to Diagnosis and Management (with internet updates)","author":"Sadovnick","year":"2001"},{"key":"S0317167100001207_ref012","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0197-4580(98)00022-0","article-title":"Consensus report of the working group on: \u201cMolecular and biochemical markers of Alzheimer\u2019s disease\u201d","volume":"19","year":"1998","journal-title":"Neurobiol Aging"},{"key":"S0317167100001207_ref007","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91705-Q"},{"key":"S0317167100001207_ref015","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199211123272001"},{"key":"S0317167100001207_ref029","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.2000.10.1267"},{"key":"S0317167100001207_ref024","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530200063039"},{"key":"S0317167100001207_ref011","article-title":"Serum p97 as a screening test for Alzheimer\u2019s disease","volume":"19","author":"Jeffries","year":"1998","journal-title":"Neurobiol Aging"},{"key":"S0317167100001207_ref028","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-199706000-00009"},{"key":"S0317167100001207_ref019","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"S0317167100001207_ref030","article-title":"The recognition and management of dementing disorders: conclusions from the Canadian Consensus Conference on Dementia","volume":"160","author":"Patterson","year":"1999","journal-title":"Can Med Assoc J"},{"key":"S0317167100001207_ref004","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.9.1787"},{"key":"S0317167100001207_ref003","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19970725)74:4<380::AID-AJMG8>3.0.CO;2-T"},{"key":"S0317167100001207_ref021","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370110406"},{"key":"S0317167100001207_ref002","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.11.2045"},{"key":"S0317167100001207_ref010","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2825(1998)12:5<285::AID-JCLA6>3.0.CO;2-5"},{"key":"S0317167100001207_ref026","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)90284-6"},{"key":"S0317167100001207_ref023","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380105"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167100001207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T10:04:52Z","timestamp":1650794692000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167100001207\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5]]},"references-count":31,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2001,5]]}},"alternative-id":["S0317167100001207"],"URL":"https:\/\/doi.org\/10.1017\/s0317167100001207","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,5]]}}}