{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T11:13:40Z","timestamp":1690542820336},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:00:00Z","timestamp":1417478400000},"content-version":"unspecified","delay-in-days":4871,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. j. neurol. sci."],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:sec id=\"S0317167100001438_abs1\"><jats:title><jats:bold><jats:italic>Background:<\/jats:italic><\/jats:bold><\/jats:title><jats:p>Infective endocarditis is associated with serious neurological sequelae.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100001438_abs2\"><jats:title><jats:bold><jats:italic>Objective:<\/jats:italic><\/jats:bold><\/jats:title><jats:p>Here, we report a patient with Staphylococcus aureus endocarditis, secondary to congenital heart disease, with subacute onset of multiple neurological complications.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100001438_abs3\"><jats:title><jats:bold><jats:italic>Results:<\/jats:italic><\/jats:bold><\/jats:title><jats:p>Despite prompt antibiotic treatment with rapid sterilization of blood cultures, the patient died with brain herniation within 96 hours of admission. Neuropathological examination showed intraparenchymal hemorrhages, mycotic aneurysms, micro-abscesses and septic arteritis with accompanying infarction. Immunocytochemical studies revealed enhanced CD45 and GFAP immunoreactivity, together with adenosine A1 receptor detection on macrophages and microglia.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100001438_abs4\"><jats:title><jats:bold><jats:italic>Conclusion:<\/jats:italic><\/jats:bold><\/jats:title><jats:p>Infective endocarditis is associated with multiple neuropathological lesions, which may contribute to its poor clinical outcome and activation of cells of monocyte-microglial lineage throughout the brain.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0317167100001438","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T10:38:34Z","timestamp":1418380714000},"page":"260-264","source":"Crossref","is-referenced-by-count":8,"title":["Encephalopathy with Staphylococcal Endocarditis: Multiple Neuropathological Findings"],"prefix":"10.1017","volume":"28","author":[{"given":"S.G.","family":"Weeks","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.J.","family":"Doig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.N.","family":"Auer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Power","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.J.","family":"Gill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,12,2]]},"reference":[{"key":"S0317167100001438_ref003","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.18.6.1048"},{"key":"S0317167100001438_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(97)01169-7"},{"key":"S0317167100001438_ref010","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.6.1233"},{"key":"S0317167100001438_ref006","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19960415)44:2<165::AID-JNR9>3.0.CO;2-B"},{"key":"S0317167100001438_ref008","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197807000-00004"},{"key":"S0317167100001438_ref004","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.2.173"},{"key":"S0317167100001438_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(96)10047-3"},{"key":"S0317167100001438_ref005","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.11.1461"},{"key":"S0317167100001438_ref013","first-page":"380","article-title":"Cell-Mediated and Humoral Effector Responses","author":"Kuby","year":"1997","journal-title":"Immunology"},{"key":"S0317167100001438_ref015","doi-asserted-by":"publisher","DOI":"10.1021\/jm960682u"},{"key":"S0317167100001438_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)00827-9"},{"key":"S0317167100001438_ref009","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.21.5.695"},{"key":"S0317167100001438_ref002","first-page":"331","volume-title":"Central Nervous System Infectious Diseases and Therapy","author":"Solenksi","year":"1997"},{"key":"S0317167100001438_ref007","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0733-8619(18)30161-0","article-title":"Neurologic complications of infectiveendocarditis","volume":"11","author":"Tunkel","year":"1993","journal-title":"Neurol Clin"},{"key":"S0317167100001438_ref014","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199905)45:5<633::AID-ANA12>3.0.CO;2-X"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167100001438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T19:40:15Z","timestamp":1557258015000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167100001438\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,8]]}},"alternative-id":["S0317167100001438"],"URL":"https:\/\/doi.org\/10.1017\/s0317167100001438","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,8]]}}}