{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:54:30Z","timestamp":1787921670866,"version":"build-2784847793"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:00:00Z","timestamp":1417478400000},"content-version":"unspecified","delay-in-days":4687,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. j. neurol. sci."],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:sec id=\"S0317167100001712_abs1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Few data are available about the diagnostic yield of the lactate stress test (LST) in a large group of patients with mitochondriopathy (MCP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167100001712_abs2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Serum lactate was determined once before, three times during, and once after a 15-minute, constant 30W workload on a bicycle in 62 controls, aged 17 to 84 years, 155 patients with MCP, aged 17 to 87 years, and 31 patients with neurological disorders other than MCP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167100001712_abs3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Lactate's upper reference limits at rest, 5, 10, 15 minutes after starting, and 15 minutes after finishing the exercise were 2.0, 2.1, 2.1, 2.1 and 1.8 mmol\/l respectively. The test was regarded abnormal if more than two of the five lactate values exceeded the cut-off levels. Among the 103 patients with abnormal LST, 64 (62 %) had normal resting lactate. The sensitivity of the test was 67% and the specificity 94%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0317167100001712_abs4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The LST proved to have a high sensitivity and specificity in the detection of patients with MCP, being thus a simple but powerful tool to assess the impaired oxidative metabolism in MCP patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0317167100001712","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T10:37:05Z","timestamp":1418380625000},"page":"49-53","source":"Crossref","is-referenced-by-count":31,"title":["Lactate Stress Testing in 155 Patients with Mitochondriopathy"],"prefix":"10.1017","volume":"29","author":[{"given":"Josef","family":"Finsterer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Milvay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2014,12,2]]},"reference":[{"key":"S0317167100001712_ref022","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(01)00371-5"},{"key":"S0317167100001712_ref019","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(75)80217-4"},{"key":"S0317167100001712_ref004","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007537"},{"key":"S0317167100001712_ref007","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7506-0585-4.50009-5"},{"key":"S0317167100001712_ref008","first-page":"545","article-title":"Laktat- und Pyruvatspiegel in derDiagnostik mitochondrialer Myopathien","volume":"60","author":"Zierz","year":"1989","journal-title":"Nervenarzt"},{"key":"S0317167100001712_ref013","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410400416"},{"key":"S0317167100001712_ref020","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(99)00047-4"},{"key":"S0317167100001712_ref015","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1995.tb07007.x"},{"key":"S0317167100001712_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(81)90115-5"},{"key":"S0317167100001712_ref005","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1136\/jnnp.52.9.1090","article-title":"Screening for mitochondrial cytopathies: thesub-anaerobic threshold exercise test (SATET)","volume":"52","author":"Hashef","year":"1989","journal-title":"J NeurolNeurosurg Psychiatry"},{"key":"S0317167100001712_ref002","first-page":"1610","volume-title":"Basic and Clinical","author":"Morgan-Hughes","year":"1994"},{"key":"S0317167100001712_ref001","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410170602"},{"key":"S0317167100001712_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(98)00170-1"},{"key":"S0317167100001712_ref021","first-page":"339","article-title":"Presentation andclinical investigation of mitochondrial respiratory chain disease","volume":"118","author":"Jackson","year":"1995","journal-title":"A study of 51 patients. 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