{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T19:23:33Z","timestamp":1648841013941},"reference-count":12,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:00:00Z","timestamp":1417478400000},"content-version":"unspecified","delay-in-days":3775,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. j. neurol. sci."],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:sec id=\"S0317167100003541_abs1\"><jats:title>Background:<\/jats:title><jats:p>Endozepine-4 stupor is a rare disorder. It presents with recurrent episodes of stupor and coma. Endozepine-4 levels are elevated during an attack with electroencephalogram showing fast activity during the ictal phase. There is no specific treatment and various drugs have been tried without long-term benefit.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100003541_abs2\"><jats:title>Method:<\/jats:title><jats:p>We used the vigilance promoting drug modafinil to prevent such attacks in a case presented with endozepine stupor.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100003541_abs3\"><jats:title>Results:<\/jats:title><jats:p>The vigilance promoting drug modafinil prevented recurrent episodes of stupor and coma in this patient at a dose of 200 mg\/day for a period of six months. Upon withdrawal of the drug, the patient experienced recurrent episodes and on reinstitution of modafinil she has remained asymptomatic in the following one year.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0317167100003541","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T15:35:30Z","timestamp":1418398530000},"page":"409-411","source":"Crossref","is-referenced-by-count":4,"title":["Modafinil in Endozepine Stupor. A Case Report"],"prefix":"10.1017","volume":"31","author":[{"given":"Sharon","family":"Scott","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iftekhar","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,12,2]]},"reference":[{"key":"S0317167100003541_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)93011-B"},{"key":"S0317167100003541_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(00)00019-8"},{"key":"S0317167100003541_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(96)12918-9"},{"key":"S0317167100003541_ref011","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/16.7.671"},{"key":"S0317167100003541_ref010","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410310507"},{"key":"S0317167100003541_ref012","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1992.tb10952.x"},{"key":"S0317167100003541_ref003","first-page":"1166","article-title":"Randomized trial of modafinil as a treatment for the excessive daytime somnolence of narcolepsy","year":"2000","journal-title":"Neurology"},{"key":"S0317167100003541_ref007","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.1.127"},{"key":"S0317167100003541_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(98)00085-2"},{"key":"S0317167100003541_ref006","doi-asserted-by":"crossref","first-page":"8620","DOI":"10.1523\/JNEUROSCI.20-22-08620.2000","article-title":"Hypothalamic arousal regions are activated during modafinil-induced wakefulness","volume":"20","author":"Scamelli","year":"2000","journal-title":"J Neurosci"},{"key":"S0317167100003541_ref009","first-page":"A177","article-title":"Idiopathic recurring stupor: a new syndrome","volume":"45","author":"Chen","year":"1995","journal-title":"Neurology"},{"key":"S0317167100003541_ref001","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-200005000-00004"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167100003541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T21:51:20Z","timestamp":1555019480000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167100003541\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,8]]}},"alternative-id":["S0317167100003541"],"URL":"https:\/\/doi.org\/10.1017\/s0317167100003541","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,8]]}}}