{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T02:36:50Z","timestamp":1761964610531},"reference-count":11,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:00:00Z","timestamp":1417478400000},"content-version":"unspecified","delay-in-days":3502,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. j. neurol. sci."],"published-print":{"date-parts":[[2005,5]]},"abstract":"ABSTRACT:<\/jats:title>Background:<\/jats:title>Human immunodeficiency virus (HIV) infection frequently results in neurological complications but the impact of different neurological syndromes on patients' quality of life remains unknown.<\/jats:p><\/jats:sec>Methods:<\/jats:title>We investigated health-related quality of life (HRQoL) parameters among HIV\/Acquired Immune Deficiency Syndrome (AIDS) patients with and without neurological disease, including 11 dimensions of HRQoL within the Medical Outcomes Short-form Health Survey-HIV.<\/jats:p><\/jats:sec>Results:<\/jats:title>Comparisons of sociodemographic and systemic clinical variables did not differ between HIV\/AIDS patients with (n=94) and without (n=75) neurological disease. However, patients with neurological diseases exhibited significantly lower HRQoL scores compared to matched controls, which was most evident among HIV\/AIDS patients with cognitive impairment and sensory neuropathy. Prospective analysis revealed diminishing HRQoL scores prior to neurological diagnosis followed by a progressive and sustained improvement in HRQoL scores after intervention over a 96-week period.<\/jats:p><\/jats:sec>Conclusions:<\/jats:title>These studies indicate that while HIV-related neurological diseases are associated with reduced HRQoL scores, enhanced neurological care has a positive impact on HIV\/AIDS patients' overall well-being.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0317167100003978","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T15:33:05Z","timestamp":1418398385000},"page":"201-204","source":"Crossref","is-referenced-by-count":35,"title":["HIV-Related Neurological Syndromes Reduce Health-Related Quality of Life"],"prefix":"10.1017","volume":"32","author":[{"given":"Rupang","family":"Pandya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hartmut B.","family":"Krentz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. John","family":"Gill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Power","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. John","family":"Gill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,12,2]]},"reference":[{"key":"S0317167100003978_ref008","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.6.1814"},{"key":"S0317167100003978_ref011","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200401001-00011"},{"key":"S0317167100003978_ref005","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/15.6.535"},{"key":"S0317167100003978_ref004","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200007070-00004"},{"key":"S0317167100003978_ref010","first-page":"683","article-title":"Evaluating health-related wellbeingoutcomes among outpatient adults with human immunodeficiency virus infection in the HAART era","volume":"13","author":"Saunders","year":"2002","journal-title":"Int J STDAIDS"},{"key":"S0317167100003978_ref001","doi-asserted-by":"publisher","DOI":"10.3109\/13550280009006385"},{"key":"S0317167100003978_ref002","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100001682"},{"key":"S0317167100003978_ref003","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-200009002-00019"},{"key":"S0317167100003978_ref006","first-page":"106","article-title":"The changing direct costs of medicalcare for patients with HIV\/AIDS, 1995\u20132001","volume":"169","author":"Krentz","year":"2003","journal-title":"Can Med Assoc J"},{"key":"S0317167100003978_ref007","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1212\/WNL.41.6.778","article-title":"Nomenclature and research case definitions forneurologic manifestations of human immunodeficiency virustype 1 (HIV-1) infection. Report of a Working Group of the American Academy of Neurology AIDS Task Force [seecomments]","volume":"41","author":"Janssen","year":"1991","journal-title":"Neurology"},{"key":"S0317167100003978_ref009","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012522013817"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167100003978","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T20:59:22Z","timestamp":1556917162000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167100003978\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["S0317167100003978"],"URL":"https:\/\/doi.org\/10.1017\/s0317167100003978","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5]]}}}