{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:20:47Z","timestamp":1761744047835},"reference-count":6,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:00:00Z","timestamp":1417478400000},"content-version":"unspecified","delay-in-days":3410,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. j. neurol. sci."],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:sec id=\"S0317167100004261_abs1\"><jats:title>Background:<\/jats:title><jats:p>Transient focal lesions in the splenium of the corpus callosum (SCC) have been previously described in patients with epilepsy or without epilepsy but receiving antiepileptic drugs (AED).<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100004261_abs2\"><jats:title>Case reports:<\/jats:title><jats:p>Two epileptic patients were admitted to our long-term monitoring unit. Antiepileptic drugs were completely discontinued a few days later. One patient had no seizures. The other had three attacks, the last of which occurred two days before a brain magnetic resonance imaging (MRI) was performed. In both cases brain MRI showed a lesion in the SCC characterized by high signal on T2-weighted images and no enhancement after Gadolinium infusion. The patients were discharged with their pre-admission medications. A follow-up MRI five weeks later showed resolution of the SCC lesions.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100004261_abs3\"><jats:title>Conclusions:<\/jats:title><jats:p>The pathogenesis of transient SCC lesions in epileptic patients is still unclear. In our patients, either the sudden AED withdrawal or the seizures activity may be presumed to be the cause, though an individual susceptibility must also be considered.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0317167100004261","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T10:33:09Z","timestamp":1418380389000},"page":"352-355","source":"Crossref","is-referenced-by-count":11,"title":["Transient Edematous Lesions of the Splenium in Epileptic Patients"],"prefix":"10.1017","volume":"32","author":[{"given":"Giovanna","family":"Carrara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edoardo","family":"Ferlazzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donatella","family":"Tampieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick","family":"Andermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Melanson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,12,2]]},"reference":[{"key":"S0317167100004261_ref004","first-page":"S63","article-title":"Transient lesion in the splenium of the corpus callosum in epilepsy is associated with rapid antiepileptic drug withdrawal","volume":"45","author":"Gurtler","year":"2004","journal-title":"Epilepsia"},{"key":"S0317167100004261_ref005","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-002-1679-5"},{"key":"S0317167100004261_ref003","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.70.4.459"},{"key":"S0317167100004261_ref001","volume-title":"Proceedings of the 34th Annual Meeting of the American Society of Neuroradiology: June 21-27, 1996; Seattle","author":"Chason","year":"1996"},{"key":"S0317167100004261_ref006","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000058754.99940.11"},{"key":"S0317167100004261_ref002","first-page":"125","article-title":"Focal lesion in the splenium of the corpus callosum in epileptic patients: antiepileptic drug toxicity?","volume":"20","author":"Kim","year":"1999","journal-title":"AJNR Am J Neuroradiol"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167100004261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T03:15:06Z","timestamp":1554952506000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167100004261\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":6,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["S0317167100004261"],"URL":"https:\/\/doi.org\/10.1017\/s0317167100004261","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8]]}}}