{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T22:55:47Z","timestamp":1696632947962},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:00:00Z","timestamp":1417478400000},"content-version":"unspecified","delay-in-days":3502,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. j. neurol. sci."],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:sec id=\"S0317167100004443_abs1\"><jats:title>Objective:<\/jats:title><jats:p>The aim of the present study was to assess visual alterations in a population of Argentine patients treated with the antiepileptic drug vigabatrin.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100004443_abs2\"><jats:title>Methods:<\/jats:title><jats:p>Twenty patients receiving vigabatrin and 15 patients receiving carbamazepine were examined with automated perimetry using a Humphrey 120-point full screening strategy. In addition, scotopic flash electroretinograms were performed.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100004443_abs3\"><jats:title>Results:<\/jats:title><jats:p>Of 20 patients treated with vigabatrin, two were unable to cooperate with testing. Of the remaining 18 patients, all but two showed at least one non-detected point inside the central 40\u00b0 of the visual field of each eye. Of the 15 carbamazepine-treated patients, three were unable to perform the study. None of the remaining 12 patients showed visual field defects. Both a- and b-wave amplitudes of the scotopic electroretinogram were significantly reduced in 12 patients receiving vigabatrin.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100004443_abs4\"><jats:title>Conclusions:<\/jats:title><jats:p>Visual field defects among patients on vigabatrin therapy may occur with a higher frequency than previously recognized. The Humphrey 120-points full field screening test and electroretinography are useful tools to assess the visual dysfunction associated with vigabatrin.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0317167100004443","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T15:30:34Z","timestamp":1418398234000},"page":"459-464","source":"Crossref","is-referenced-by-count":6,"title":["Visual Defects Associated with Vigabatrin: A Study of Epileptic Argentine Patients"],"prefix":"10.1017","volume":"32","author":[{"given":"Mar\u00eda Cecilia","family":"Moreno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda","family":"Giagante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Saidon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Kochen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Benozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth E.","family":"Rosenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,12,2]]},"reference":[{"key":"S0317167100004443_ref014","doi-asserted-by":"publisher","DOI":"10.1023\/A:1014603229383"},{"key":"S0317167100004443_ref020","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.2.196"},{"key":"S0317167100004443_ref007","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.67.6.716"},{"key":"S0317167100004443_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(86)90052-7"},{"key":"S0317167100004443_ref012","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.1.40"},{"key":"S0317167100004443_ref019","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(88)90147-2"},{"key":"S0317167100004443_ref001","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.314.7075.180"},{"key":"S0317167100004443_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/S1059-1311(00)90527-2"},{"key":"S0317167100004443_ref022","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(01)00638-8"},{"key":"S0317167100004443_ref005","first-page":"1104","article-title":"Visual fieldchanges secondary to vigabatrin treatment","volume":"31","author":"Mauri-Llerda","year":"2000","journal-title":"Rev Neurol"},{"key":"S0317167100004443_ref011","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.3.347"},{"key":"S0317167100004443_ref006","volume-title":"The risk of visual field defects and the use ofvigabatrin","author":"Martinez","year":"1997"},{"key":"S0317167100004443_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(99)90345-7"},{"key":"S0317167100004443_ref017","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523800008932"},{"key":"S0317167100004443_ref002","doi-asserted-by":"publisher","DOI":"10.1023\/A:1002045223358"},{"key":"S0317167100004443_ref021","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1990.tb15803.x"},{"key":"S0317167100004443_ref009","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0420.2000.078005580.x"},{"key":"S0317167100004443_ref008","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.9.2082"},{"key":"S0317167100004443_ref018","doi-asserted-by":"publisher","DOI":"10.1177\/019262338701500203"},{"key":"S0317167100004443_ref010","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.3.614"},{"key":"S0317167100004443_ref003","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.5.922"},{"key":"S0317167100004443_ref016","doi-asserted-by":"publisher","DOI":"10.3109\/00207459908994792"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167100004443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T21:00:03Z","timestamp":1556917203000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167100004443\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["S0317167100004443"],"URL":"https:\/\/doi.org\/10.1017\/s0317167100004443","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5]]}}}