{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T21:57:26Z","timestamp":1772661446844,"version":"3.50.1"},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:00:00Z","timestamp":1417478400000},"content-version":"unspecified","delay-in-days":3226,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. j. neurol. sci."],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title>\n\t  <jats:sec id=\"S0317167100004789_abs1\">\n\t    <jats:title>Background:<\/jats:title>\n\t    <jats:p>Medulloblastoma is the most common malignant central nervous system tumour in children but, in contrast, quite rare in adults. Hemispheric, rather than midline, cerebellar medulloblastomas are more common in older children and adults. We present the unusual case of a 71-year-old man who presented with a fourth ventricular mass that proved to be a medulloblastoma.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0317167100004789_abs2\">\n\t    <jats:title>Methods:<\/jats:title>\n\t    <jats:p>A 71-year-old man presented with progressive balance problems, slurred speech and double vision. A CT scan of the brain revealed a hyperattenuating, partially calcified, avidly enhancing mass within the fourth ventricle. Diffusion weighted MRI showed restricted diffusion within the mass. The patient underwent a midline suboccipital craniotomy and a subtotal resection was achieved.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0317167100004789_abs3\">\n\t    <jats:title>Results:<\/jats:title>\n\t    <jats:p>Histological examination showed a densely cellular neoplasm composed of small cells with a tendency towards neuroblastic rosette formation. Most cells were strongly positive for neuron-specific enolase and synaptophysin. Ultrastructurally, tumour cells showed evidence of neuronal differentiation. These findings were consistent with a classical medulloblastoma.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0317167100004789_abs4\">\n\t    <jats:title>Conclusion:<\/jats:title>\n\t    <jats:p>Adult medulloblastoma should be considered in the differential diagnosis of a partially calcified hyperattenuating mass within the fourth ventricle.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1017\/s0317167100004789","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T15:30:25Z","timestamp":1418398225000},"page":"101-104","source":"Crossref","is-referenced-by-count":7,"title":["Midline Cerebellar Medulloblastoma in a Seventy-One-Year-Old Patient"],"prefix":"10.1017","volume":"33","author":[{"given":"Raymund L.","family":"Yong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eoin C.","family":"Kavanagh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Fenton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina","family":"Dorovini-Zis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manraj K.S.","family":"Heran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles S.","family":"Haw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,12,2]]},"reference":[{"key":"S0317167100004789_manual_ref-8","doi-asserted-by":"publisher","DOI":"10.1007\/BF00172602"},{"key":"S0317167100004789_manual_ref-3","doi-asserted-by":"crossref","first-page":"536","DOI":"10.3171\/jns.1989.70.4.0536","article-title":"Adult cerebellarmedulloblastomas: the pathological, radiographic, and clinical disease spectrum","volume":"70","author":"Hubbard","year":"89","journal-title":"J Neurosurg"},{"key":"S0317167100004789_manual_ref-7","doi-asserted-by":"publisher","DOI":"10.1159\/000121121"},{"key":"S0317167100004789_manual_ref-5","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1944.02290330002001"},{"key":"S0317167100004789_manual_ref-9","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800215)45:4<670::AID-CNCR2820450409>3.0.CO;2-K"},{"key":"S0317167100004789_manual_ref-6","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1227\/00006123-198707000-00017","article-title":"Cerebellar medullo-blastoma ina 73-year-old woman","volume":"21","author":"Kepes","year":"87","journal-title":"Neurosurgy"},{"key":"S0317167100004789_manual_ref-2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.236035168"},{"key":"S0317167100004789_manual_ref-10","doi-asserted-by":"publisher","DOI":"10.1053\/ctrv.1998.0096"},{"key":"S0317167100004789_manual_ref-11","first-page":"43","article-title":"The treatment and prognosisof medulloblastoma in children","volume":"105","author":"Bloom","year":"69","journal-title":"AJR Am J Radiol"},{"key":"S0317167100004789_manual_ref-4","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/(SICI)1097-0215(19990301)80:5<689::AID-IJC10>3.0.CO;2-G","article-title":"Epidemiology of adultmedulloblastoma","volume":"80","author":"Giordana","year":"1999","journal-title":"Int J Cancer"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167100004789","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T23:45:23Z","timestamp":1750463123000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167100004789\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["S0317167100004789"],"URL":"https:\/\/doi.org\/10.1017\/s0317167100004789","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2]]}}}