{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T01:45:23Z","timestamp":1784684723983,"version":"3.55.0"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:00:00Z","timestamp":1417478400000},"content-version":"unspecified","delay-in-days":3076,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. j. neurol. sci."],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>ABSTRACT:<\/jats:title><jats:sec id=\"S0317167100005060_abs1\"><jats:title>Background:<\/jats:title><jats:p>Dopamine agonists are widely used in the treatment of pituitary prolactinomas. We report a case of inferior mesial frontal lobe (gyrus rectus) and chiasmal herniations into an enlarged sella following successful medical treatment of a pituitary macroadenoma.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100005060_abs2\"><jats:title>Method:<\/jats:title><jats:p>A 71-year-old healthy man presented to medical attention with visual complaints. On examination, he was found to have bitemporal hemianopsia. Endocrine evaluation revealed an elevated prolactin level. He was treated medically with a dopamine agonist (bromocriptine).<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100005060_abs3\"><jats:title>Results:<\/jats:title><jats:p>Evaluation after one year of medical treatment revealed stabilization of the patient's vision, with a significant bitemporal field loss. Serum prolactin levels normalized (5.16 ng\/ml). The MRI of the sella showed almost complete disappearance of the tumor, resulting in right mesial frontal lobe herniation inferiorly into an enlarged sella with associated chiasmal deformation.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100005060_abs4\"><jats:title>Conclusions:<\/jats:title><jats:p>We report a case where successful medical treatment of a large pituitary prolactinoma has resulted in inferior frontal lobe and chiasmal herniatons into an enlarged sella.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0317167100005060","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T10:30:24Z","timestamp":1418380224000},"page":"240-242","source":"Crossref","is-referenced-by-count":13,"title":["Brain &amp; Chiasmal Herniations into Sella after Medical Treatment of Prolactinoma"],"prefix":"10.1017","volume":"33","author":[{"given":"M.H.","family":"Bangash","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.B.","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.O.","family":"Holness","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2014,12,2]]},"reference":[{"key":"S0317167100005060_ref014","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.1.111"},{"key":"S0317167100005060_ref015","first-page":"397","article-title":"Intrasellar cerebral hernia after prolonged radiotherapy of acromegaly","volume":"37-38","author":"Gros","year":"1950","journal-title":"Montp Med."},{"key":"S0317167100005060_ref012","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2000.01039.x"},{"key":"S0317167100005060_ref017","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.7.8645"},{"key":"S0317167100005060_ref009","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.152.3.597"},{"key":"S0317167100005060_ref007","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:28:1:101"},{"key":"S0317167100005060_ref016","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-003-0134-y"},{"key":"S0317167100005060_ref001","doi-asserted-by":"publisher","DOI":"10.1385\/1-59259-390-9:21"},{"key":"S0317167100005060_ref011","first-page":"252","article-title":"Chiasmal herniation as a complication of bromocriptine therapy.","volume":"16","author":"Taxel","year":"1996"},{"key":"S0317167100005060_ref013","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.31.3.214"},{"key":"S0317167100005060_ref010","first-page":"1279","article-title":"Macroprolactinomas: serial MR imaging in long-term bromocriptine therapy","volume":"13","author":"Lundin","year":"1992","journal-title":"Am J Neuroradiol."},{"key":"S0317167100005060_ref019","first-page":"1189","article-title":"Secondary empty sella syndrome: report of three cases and review of the literature","volume":"10","author":"Keyaki","year":"1982","journal-title":"No Shinkei Geka."},{"key":"S0317167100005060_ref004","first-page":"258","article-title":"Optimization of magnetic resonance imaging for sellar lesions","volume":"6","author":"Tarr","year":"2000","journal-title":"Techniques in Neurosurgery."},{"key":"S0317167100005060_ref008","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.289.6452.1101"},{"key":"S0317167100005060_ref005","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012905415868"},{"key":"S0317167100005060_ref018","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1975.43.3.0288"},{"key":"S0317167100005060_ref006","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-60-4-698"},{"key":"S0317167100005060_ref002","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200210001-00009"},{"key":"S0317167100005060_ref003","first-page":"1","volume-title":"Tumors of the Pituitary Gland. 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