{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:16:34Z","timestamp":1791299794390,"version":"4.1.0"},"reference-count":65,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:00:00Z","timestamp":1417478400000},"content-version":"unspecified","delay-in-days":1980,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. j. neurol. sci."],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:sec id=\"S0317167100007794_abs1\"><jats:title>Background:<\/jats:title><jats:p>The onset of progressive cerebellar ataxia in early childhood is considered a key feature of ataxiatelangiectasia (A-T), accompanied by ocular apraxia, telangiectasias, immunodeficiency, cancer susceptibility and hypersensitivity to ionizing radiation.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100007794_abs2\"><jats:title>Methods:<\/jats:title><jats:p>We describe the clinical features and course of three Mennonite children who were diagnosed with A-T following the completion of therapy for lymphoid malignancies.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100007794_abs3\"><jats:title>Results:<\/jats:title><jats:p>Prior to cancer therapy, all had non-progressive atypical neurological abnormalities, with onset by age 30 months, including dysarthria, dyskinesia, hypotonia and\/or dystonia, without telangiectasias. Cerebellar ataxia was noted in only one of the children and was mild until his death at age eight years. None had severe infections. All three children were \u201ccured\u201d of their lymphoid malignancies, but experienced severe adverse effects from the treatments administered. The two children who received cranial irradiation developed supratentorial primitive neuroectodermal tumors of the brain, an association not previously described, with fatal outcomes.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100007794_abs4\"><jats:title>Conclusions:<\/jats:title><jats:p>The range of neurological presentations of A-T is broad. Ataxia and telangiectasias may be minimal or absent and the course seemingly non-progressive. The diagnosis of A-T should be considered in all children with neuromotor dysfunction or peripheral neuropathy, particularly those who develop lymphoid malignancies. The consequences of missing the diagnosis may be dire. Radiation therapy and radiomimetic drugs should be avoided in individuals with A-T.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0317167100007794","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T15:13:14Z","timestamp":1418397194000},"page":"462-467","source":"Crossref","is-referenced-by-count":35,"title":["Ataxia-Telangiectasia: Atypical Presentation and Toxicity of Cancer Treatment"],"prefix":"10.1017","volume":"36","author":[{"given":"Rochelle A.","family":"Yanofsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sashi S.","family":"Seshia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika J.","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent","family":"Stobart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl R.","family":"Greenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances A.","family":"Booth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitra","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc R.","family":"Del Bigio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens J.","family":"Wrogemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Fike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Gatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2014,12,2]]},"reference":[{"key":"S0317167100007794_ref065","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199812)31:6<491::AID-MPO5>3.0.CO;2-B"},{"key":"S0317167100007794_ref062","doi-asserted-by":"publisher","DOI":"10.1016\/S1071-9091(03)00026-3"},{"key":"S0317167100007794_ref060","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.123879"},{"key":"S0317167100007794_ref058","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(91)90164-P"},{"key":"S0317167100007794_ref052","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2006.05.011"},{"key":"S0317167100007794_ref051","first-page":"82","article-title":"Ataxia-telangiectasia and malignancies","volume":"26","author":"Berkel","year":"1974","journal-title":"Turk J Pediatr."},{"key":"S0317167100007794_ref053","doi-asserted-by":"publisher","DOI":"10.1007\/s002470050578"},{"key":"S0317167100007794_ref056","doi-asserted-by":"publisher","DOI":"10.1136\/adc.63.9.1079"},{"key":"S0317167100007794_ref015","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.094268"},{"key":"S0317167100007794_ref008","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1542\/peds.21.4.526","article-title":"Ataxia-Telangiectasia. 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