{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:18:11Z","timestamp":1767665891323},"reference-count":38,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:00:00Z","timestamp":1417478400000},"content-version":"unspecified","delay-in-days":2222,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. j. neurol. sci."],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:sec id=\"S0317167100009410_abs1\"><jats:title>Background:<\/jats:title><jats:p>Current cognitive models propose that multiple processes are involved in reading and writing.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100009410_abs2\"><jats:title>Objective:<\/jats:title><jats:p>Our goal was to use linguistic analyses to clarify the cognitive dysfunction behind two classic alexic syndromes.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100009410_abs3\"><jats:title>Methods:<\/jats:title><jats:p>We report four experiments on two patients, one with alexia without agraphia following occipitotemporal lesions, and one with alexia with agraphia from a left angular gyral lesion.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100009410_abs4\"><jats:title>Results:<\/jats:title><jats:p>The patient with occipital lesions had trouble discriminating real letters from foils and his reading varied with word-length but not with linguistic variables such as part of speech, word frequency or imageability. He read pseudo-words and words with regular spelling better, indicating preserved use of grapheme-to-phoneme pronunciation rules. His writing showed errors that reflected reliance on \u2018phoneme-to-grapheme\u2019 spelling rules. In contrast, the patient with a left angular gyral lesion showed better recognition of letters, words and their meanings. His reading was better for words with high imageability but displayed semantic errors and an inability to use \u2018grapheme-to-phoneme\u2019 rules, features consistent with deep dyslexia. His agraphia showed impaired access to both an internal lexicon and \u2018phoneme-to-grapheme\u2019 rules.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100009410_abs5\"><jats:title>Conclusion:<\/jats:title><jats:p>Some cases of pure alexia may be a perceptual word-form agnosia, with loss of internal representations of letters and words, while the angular gyral syndrome of alexia with agraphia is a linguistic deep dyslexia. The presence or absence of agraphia does not always distinguish between the two; rather, writing can mirror the reading deficits, being more obvious and profound in the case of an angular gyral syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0317167100009410","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T15:15:22Z","timestamp":1418397322000},"page":"616-624","source":"Crossref","is-referenced-by-count":21,"title":["Alexia With and Without Agraphia: An Assessment of Two Classical Syndromes"],"prefix":"10.1017","volume":"35","author":[{"given":"Claire A.","family":"Sheldon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George L.","family":"Malcolm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason 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