{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T14:00:21Z","timestamp":1792332021302,"version":"4.4.0"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:00:00Z","timestamp":1417478400000},"content-version":"unspecified","delay-in-days":2222,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. j. neurol. sci."],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:sec id=\"S0317167100009422_abs1\"><jats:title>Background:<\/jats:title><jats:p>Sporadic Creutzfeldt-Jakob disease (CJD) is a fatal, transmissible spongiform encephalopathy characterized by rapidly progressive dementia, myoclonus, ataxia and akinetic mutism. The underlying mechanism is believed to be a conformational change of a native prion protein which characteristically fails to provoke an immune response. Commensurate with the latter, cerebrospinal fluid (CSF) classically exhibits a non-inflammatory profile.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100009422_abs2\"><jats:title>Cases:<\/jats:title><jats:p>We report two patients with pathologically-proven sporadic CJD presenting with a significant CSF pleocytosis.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100009422_abs3\"><jats:title>Conclusion:<\/jats:title><jats:p>Although uncommon, the presence of an inflammatory CSF profile should not exclude the diagnosis of sporadic CJD.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0317167100009422","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T10:15:22Z","timestamp":1418379322000},"page":"625-629","source":"Crossref","is-referenced-by-count":5,"title":["Inflammatory Cerebrospinal Fluid in Sporadic Creutzfeldt-Jakob Disease"],"prefix":"10.1017","volume":"35","author":[{"given":"Esther","family":"Bui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Ehrensperger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetrios J.","family":"Sahlas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Bergeron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael S.","family":"Glikstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Aviv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyman 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