{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T06:26:16Z","timestamp":1771655176137,"version":"3.50.1"},"reference-count":59,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:00:00Z","timestamp":1417478400000},"content-version":"unspecified","delay-in-days":1553,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. j. neurol. sci."],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:sec id=\"S0317167100010878_abs1\"><jats:title>Background:<\/jats:title><jats:p>Scedosporial infections are usually encountered in the immunocompromised patients. However, they are now emerging in the immunocompetent population and have an affinity for the central nervous system. They represent a therapeutic challenge, since they are highly resistant to most antifungal medications.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100010878_abs2\"><jats:title>Methods:<\/jats:title><jats:p>We report the case of an immunocompetent patient with multiple cerebral abscesses secondary to<jats:italic>Scedosporium apiospermum<\/jats:italic>following extracorporeal membrane oxygenation (ECMO) and review the literature about this challenging cerebral infection.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100010878_abs3\"><jats:title>Results:<\/jats:title><jats:p>A previously healthy 33-year-old male admitted to the hospital for a community-acquired pneumonia requiring ECMO subsequently developed multiple cerebral abscesses. He was empirically treated with caspofungin, which was changed to voriconazole once surgical aspiration revealed<jats:italic>Scedosporium apiospermum.<\/jats:italic>Despite multiple aspirations, decompressive craniectomy to alleviate intracranial pressure, and an appropriate antifungal agent, the patient did not survive this aggressive infection.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100010878_abs4\"><jats:title>Conclusion:<\/jats:title><jats:p>Brain abscesses with<jats:italic>Scedosporium apiospermum<\/jats:italic>present a therapeutic challenge. High clinical suspicion leading to early appropriate antifungal therapy and combined surgical interventions might improve the prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0317167100010878","type":"journal-article","created":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T18:41:31Z","timestamp":1417545691000},"page":"671-676","source":"Crossref","is-referenced-by-count":9,"title":["Scedosporium Cerebral Abscesses After Extra-Corporeal Membrane 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