{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T01:50:23Z","timestamp":1782179423999,"version":"3.54.5"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:00:00Z","timestamp":1417478400000},"content-version":"unspecified","delay-in-days":1066,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p>Brain biopsy plays a crucial role in the exploration of suspect white matter lesions in the differential diagnosis of primary central nervous system lymphoma (PCNSL) and inflammatory demyelination. We present the case of a previously healthy, immunocompetent woman, aged fifty-nine, who developed a histologically confirmed demyelinating white matter lesion months prior to the manifestation of a PCNSL. Similar cases of \u201csentinel lesions\u201d preceding a PCNSL have been reported. In a literature review, we compared the diagnostic features that may be useful to differentiate a PCNSL from inflammatory demyelinating disease in older age. We conclude that the occurrence of large, contrast-enhancing cerebral lesions in older patients with a relapsing-remitting disease course and steroid-resistant vision disorders should lead to the consideration of a PCNSL.<\/jats:p>","DOI":"10.1017\/s0317167100012610","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T15:04:09Z","timestamp":1418396649000},"page":"6-10","source":"Crossref","is-referenced-by-count":35,"title":["Inflammatory Demyelinating Brain Lesions Heralding Primary CNS Lymphoma"],"prefix":"10.1017","volume":"39","author":[{"given":"Leila","family":"Husseini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Reifenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Peter","family":"Hartung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd C.","family":"Kieseier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2014,12,2]]},"reference":[{"key":"S0317167100012610_ref016","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/117.1.49"},{"key":"S0317167100012610_ref019","author":"Deangelis","year":"2006","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"S0317167100012610_ref001","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-004-1360-8"},{"key":"S0317167100012610_ref013","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-199912000-00005"},{"key":"S0317167100012610_ref008","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006250317940"},{"key":"S0317167100012610_ref002","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.60.1.102"},{"key":"S0317167100012610_ref009","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1673.1993.tb00099.x"},{"key":"S0317167100012610_ref011","doi-asserted-by":"publisher","DOI":"10.1177\/107327480401100502"},{"key":"S0317167100012610_ref006","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0778-x"},{"key":"S0317167100012610_ref018","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-004-3390-7"},{"key":"S0317167100012610_ref012","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930801)72:3<843::AID-CNCR2820720333>3.0.CO;2-#"},{"key":"S0317167100012610_ref007","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0395"},{"key":"S0317167100012610_ref003","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.65.6.917"},{"key":"S0317167100012610_ref014","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006298201101"},{"key":"S0317167100012610_ref004","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.70.2.259"},{"key":"S0317167100012610_ref015","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000178894.51436.54"},{"key":"S0317167100012610_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.10.011"},{"key":"S0317167100012610_ref017","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1999.0511"},{"key":"S0317167100012610_ref010","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-006-0024-8"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167100012610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T20:01:34Z","timestamp":1556308894000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167100012610\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S0317167100012610"],"URL":"https:\/\/doi.org\/10.1017\/s0317167100012610","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}