{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:19:16Z","timestamp":1791091156508,"version":"4.1.0"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:00:00Z","timestamp":1417478400000},"content-version":"unspecified","delay-in-days":1066,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec id=\"S0317167100012671_abs1\"><jats:title>Background:<\/jats:title><jats:p>The primary aim of the present study was to determine the survival rates and identify predictors of disease duration in a cohort of Huntington's disease (HD) patients from Southern Italy.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100012671_abs2\"><jats:title>Methods:<\/jats:title><jats:p>All medical records of HD patients followed between 1977 and 2008 at the Department of Neurological Sciences of Federico II University in Naples were retrospectively reviewed and 135 patients were enrolled in the analysis. At the time of data collection, 41 patients were deceased (19 males and 22 females) with a mean \u00b1 SD age at death of 56.6 \u00b1 14.9 years (range 18-83).<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100012671_abs3\"><jats:title>Results:<\/jats:title><jats:p>The median survival time was 20 years (95% CI: 18.3-21.7). Cox regression analysis showed that the number of CAG in the expanded allele (HR 1.09 for 1 point triplet increase, p=0.002) and age of onset (HR 1.05 for 1 point year increase, p=0.022) were independent and significant predictors of lower survival rates.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100012671_abs4\"><jats:title>Conclusions:<\/jats:title><jats:p>We believe that these findings are important for a better understanding of the natural history of the disease and may be relevant in designing future therapeutic trials.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0317167100012671","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T15:04:09Z","timestamp":1418396649000},"page":"48-51","source":"Crossref","is-referenced-by-count":26,"title":["Predictors of Survival in a Huntington's Disease Population from Southern 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