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On the other hand, derangement in intestinal permeability could also result from the involvement of the gastrointestinal tract over the course of the disease.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100013202_abs2\"><jats:title>Patients and methods:<\/jats:title><jats:p>The intestinal permeability of 12 non-selected PD patients was studied using a validated, non-invasive test; these results were compared to predefined age-adjusted reference values.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100013202_abs3\"><jats:title>Results:<\/jats:title><jats:p>4\/12 PD patients had abnormal gastrointestinal permeability; two had both an abnormal lactulose\/mannitol ratio and an abnormal sucrose concentration, and two an isolated abnormal result. An increased lactulose\/mannitol ratio is consistent with defect of either the enterocytes or the tight junctions between them.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100013202_abs4\"><jats:title>Conclusion:<\/jats:title><jats:p>Intestinal permeability is increased in a significant proportion of unselected PD patients with minimal gastrointestinal symptoms. 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