{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:35:22Z","timestamp":1776263722408,"version":"3.50.1"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:00:00Z","timestamp":1417478400000},"content-version":"unspecified","delay-in-days":884,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec id=\"S0317167100014001_abs1\"><jats:title>Background:<\/jats:title><jats:p>Neuromyelitis optica (NMO) and multiple sclerosis (MS) are autoimmune diseases of the central nervous system with complex pathogeneses. NMO was once considered to be a severe variant of MS. There has been more evidence that a non-synonymous exchange (rs763361\/Gly307Ser) in the gene for CD226 is linked to several autoimmune diseases including multiple sclerosis (MS). However, no studies have investigated the role of rs763361 in the pathogenesis of NMO.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100014001_abs2\"><jats:title>Objectives:<\/jats:title><jats:p>The goal of our study is to evaluate the role of CD226 Gly307Ser in neuromyelitis optica (NMO) in Southern Han Chinese.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100014001_abs3\"><jats:title>Methods:<\/jats:title><jats:p>Eight-nine NMO patients, 93 relapsing-remitting multiple sclerosis (RRMS) patients, and 122 controls (CTLs) were enrolled. The rs763361 alleles of the subjects were determined by sequencing-based typing.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100014001_abs4\"><jats:title>Results:<\/jats:title><jats:p>The results strongly support that the TT genotypes are associated with NMO but are not significantly correlated with susceptibility for MS.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100014001_abs5\"><jats:title>Conclusions:<\/jats:title><jats:p>CD226 Gly307Ser may correlate with risk of NMO in Southern Han Chinese.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0317167100014001","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T15:03:41Z","timestamp":1418396621000},"page":"488-490","source":"Crossref","is-referenced-by-count":18,"title":["CD226 Gly307Ser Association With Neuromyelitis Optica in Southern Han Chinese"],"prefix":"10.1017","volume":"39","author":[{"given":"Chao","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guansan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongqiang","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueqiang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,12,2]]},"reference":[{"key":"S0317167100014001_ref012","first-page":"491","article-title":"DNAM-1: an amplifier of immune responses as a therapeutic target in various disorders","volume":"9","author":"Elishmereni","year":"2008","journal-title":"Curr Opin Investig Drugs"},{"key":"S0317167100014001_ref019","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.4049\/jimmunol.161.4.1671","article-title":"Protein kinase C is involved in the regulation of both signaling and adhesion mediated by DNAX accessory molecule-1 receptor","volume":"161","author":"Shibuya","year":"1998","journal-title":"J Immunol"},{"key":"S0317167100014001_ref013","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2008.82"},{"key":"S0317167100014001_ref016","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2009.44"},{"key":"S0317167100014001_ref009","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2008.01172.x"},{"key":"S0317167100014001_ref007","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-008-0295-1"},{"key":"S0317167100014001_ref017","first-page":"42","article-title":"Neuromyelitis optica","volume":"13","author":"Wingerchuk","year":"2006","journal-title":"Int MS J"},{"key":"S0317167100014001_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2011.05.003"},{"key":"S0317167100014001_ref001","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2010.30"},{"key":"S0317167100014001_ref018","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22366"},{"key":"S0317167100014001_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17551-X"},{"key":"S0317167100014001_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2010.11.004"},{"key":"S0317167100014001_ref002","first-page":"29","article-title":"Herpes zoster and multiple sclerosis","volume":"26","author":"Ross","year":"1999","journal-title":"Can J Neurol Sci"},{"key":"S0317167100014001_ref015","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2010.01568.x"},{"key":"S0317167100014001_ref006","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-11-31"},{"key":"S0317167100014001_ref011","first-page":"2125","article-title":"For the South Japan Multiple Sclerosis Genetics Consortium","volume":"76","author":"Fang","year":"2011","journal-title":"Interleukin-7 receptor alpha gene polymorphism influences multiple sclerosis risk in Asians. Neurology"},{"key":"S0317167100014001_ref014","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2008.83"},{"key":"S0317167100014001_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(00)00173-7"},{"key":"S0317167100014001_ref008","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/122.9.1689"},{"key":"S0317167100014001_ref020","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030958"},{"key":"S0317167100014001_ref021","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110199"},{"key":"S0317167100014001_ref022","doi-asserted-by":"publisher","DOI":"10.1002\/art.30204"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167100014001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T16:54:06Z","timestamp":1690736046000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167100014001\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0317167100014001"],"URL":"https:\/\/doi.org\/10.1017\/s0317167100014001","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}