{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T21:45:38Z","timestamp":1766180738509},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:00:00Z","timestamp":1417478400000},"content-version":"unspecified","delay-in-days":884,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec id=\"S0317167100014062_abs1\"><jats:title>Background:<\/jats:title><jats:p>Progressive external ophthalmoplegia (PEO) is a mitochondrial myopathy of ocular muscles. Diagnostic investigation usually involves limb skeletal muscle biopsy and molecular genetic studies, although diagnostic yield tends to be low. The purpose of this study was to evaluate the diagnostic yield obtained by analysis of levator palpebrae (LP) muscle tissue.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100014062_abs2\"><jats:title>Methods:<\/jats:title><jats:p>This is a clinicopathologic study of 8 patients with a diagnosis of PEO, who had LP muscle biopsies as part of oculoplastic procedures. Six of these patients also had limb muscle biopsies. Histopathology, electron microscopy and genetic studies were performed.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100014062_abs3\"><jats:title>Results:<\/jats:title><jats:p>Diagnostic histopathologic findings were present in 4\/6 quadriceps biopsies, and 7\/8 LP biopsies. Genetic testing on DNA extracted from LP muscle revealed abnormalities in 4 patients.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100014062_abs4\"><jats:title>Conclusion:<\/jats:title><jats:p>In patients whose LP muscle demonstrate both genetic defects and histopathological abnormalities, the diagnosis of PEO can be confirmed without limb muscle biopsy. Patients having LP resection during oculoplastics procedures for treatment of ptosis may therefore be able to avoid a separate procedure for limb muscle biopsy. Further study is required to determine the specificity of these findings.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0317167100014062","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T15:03:41Z","timestamp":1418396621000},"page":"520-524","source":"Crossref","is-referenced-by-count":3,"title":["Levator Palpebrae Biopsy and Diagnosis of Progressive External Ophthalmoplegia"],"prefix":"10.1017","volume":"39","author":[{"given":"Gerald","family":"Pfeffer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula J.","family":"Waters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Maguire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary D.","family":"Vallance","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. A.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle M.","family":"Mezei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,12,2]]},"reference":[{"key":"S0317167100014062_ref006","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-007-0603-8"},{"key":"S0317167100014062_ref002","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181aae814"},{"key":"S0317167100014062_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(02)01009-6"},{"key":"S0317167100014062_ref005","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4659"},{"key":"S0317167100014062_ref003","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4660"},{"key":"S0317167100014062_ref001","doi-asserted-by":"publisher","DOI":"10.1017\/S031716710001115X"},{"key":"S0317167100014062_ref009","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.118.10.1441"},{"key":"S0317167100014062_ref008","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e3181b2fd06"},{"key":"S0317167100014062_ref007","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1980.01020031060010"},{"key":"S0317167100014062_ref010","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2004.060590"}],"container-title":["Canadian Journal of Neurological Sciences \/ Journal Canadien des Sciences Neurologiques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0317167100014062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T22:04:34Z","timestamp":1555020274000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0317167100014062\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0317167100014062"],"URL":"https:\/\/doi.org\/10.1017\/s0317167100014062","relation":{},"ISSN":["0317-1671","2057-0155"],"issn-type":[{"value":"0317-1671","type":"print"},{"value":"2057-0155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7]]}}}