{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T12:38:12Z","timestamp":1773232692490,"version":"3.50.1"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:00:00Z","timestamp":1417478400000},"content-version":"unspecified","delay-in-days":822,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:sec id=\"S0317167100015377_abs1\"><jats:title>Background:<\/jats:title><jats:p>The impact of malignant glioma resection on survival is still a matter of controversy. The lack of well-designed prospective studies as well as control of all factors in retrospective studies plays an important role in this debate. Amongst some of these uncontrolled factors, are the inclusion of different histological grades, the lack of objective methods to estimate the extent of resection and unspecified delays in post-operative imaging.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100015377_abs2\"><jats:title>Methods:<\/jats:title><jats:p>We retrospectively reviewed 126 consecutive patients with glioblastoma, operated on by the senior authors at the Centre Hospitalier Universitaire de Sherbrooke, who met the following criteria: &gt;18 years of age, newly diagnosed glioblastoma, pre-operative magnetic resonance imaging (MRI) within 2 weeks prior to surgery, and a post-operative MRI within 72 hours after surgery. Extent of tumour resection was calculated using pre and post-operative tumour delimitation on gadolinium-enhanced T1 MRI in a volumetric analysis.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100015377_abs3\"><jats:title>Results:<\/jats:title><jats:p>Applying stringent specific inclusion criteria, 126 patients were retained in the analysis. The median overall survival was 271 days and the median extent of resection was 65%. Patients with more than 90% of tumour resection had a significantly better outcome, improving median survival from 225 to 519 days (P=0.006). Other factors that significantly improved survival were the use of radiotherapy, the number of regimens and type of chemotherapy used.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100015377_abs4\"><jats:title>Conclusion:<\/jats:title><jats:p>A more aggressive approach combining maximal safe resection and use of salvage chemotherapy seems to confer a survival advantage for glioblastoma patients.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0317167100015377","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T15:04:10Z","timestamp":1418396650000},"page":"632-637","source":"Crossref","is-referenced-by-count":18,"title":["Does Extent of Resection Impact Survival in Patients Bearing Glioblastoma?"],"prefix":"10.1017","volume":"39","author":[{"given":"Nicolas","family":"Dea","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Pierre","family":"Fournier-Gosselin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Mathieu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Goffaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Fortin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,12,2]]},"reference":[{"key":"S0317167100015377_ref016","doi-asserted-by":"publisher","DOI":"10.3171\/2008.4.17536"},{"key":"S0317167100015377_ref015","first-page":"2466","article-title":"MR imaging correlates of survival in patients with high-grade gliomas","volume":"26","author":"Pope","year":"2005","journal-title":"AJNR Am J Neuroradiol"},{"key":"S0317167100015377_ref010","first-page":"45","article-title":"Early postoperative magnetic resonance imaging after resection of malignant glioma: objective evaluation of residual tumour and its influence on regrowth and prognosis","volume":"34","author":"Albert","year":"1994","journal-title":"Neurosurgery"},{"key":"S0317167100015377_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/S0720-048X(02)00027-X"},{"key":"S0317167100015377_ref003","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008267312782"},{"key":"S0317167100015377_ref014","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2006.105.1.34"},{"key":"S0317167100015377_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-3019(99)00103-2"},{"key":"S0317167100015377_ref002","first-page":"31","article-title":"Physiological studies following extirpation of right cerebral hemisphere in man","volume":"33","author":"Dandy","year":"1933","journal-title":"Bull Johns Hopkins Hosp."},{"key":"S0317167100015377_ref007","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.8.10.1475"},{"key":"S0317167100015377_ref017","first-page":"1","article-title":"Neuro-oncology: diagnosis and management of cerebral gliomas-past, present, and future","volume":"47","author":"Gutin","year":"2000","journal-title":"Neurosurgery"},{"key":"S0317167100015377_ref018","first-page":"125","article-title":"Altering the properties of the blood-brain barrier: disruption and permeabilization","volume":"61","author":"Fortin","year":"2003","journal-title":"Prog Drug Res"},{"key":"S0317167100015377_ref005","doi-asserted-by":"publisher","DOI":"10.1227\/01.neu.0000318159.21731.cf"},{"key":"S0317167100015377_ref019","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21112"},{"key":"S0317167100015377_ref008","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-005-1397-1"},{"key":"S0317167100015377_ref006","volume-title":"Cochrane Database Syst. 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