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It is a wide spectrum anticonvulsant, approved in a number of countries for the treatment of LGS. In a randomized controlled trial in the LGS population, adjunctive rufinamide therapy has been shown to offer significantly greater reduction in total seizure frequency and tonic-atonic seizure frequency in comparison to placebo. Efficacy has been assessed over three years and appears to be sustained. Most adverse events were cognitive (e.g. somnolence) or gastrointestinal in nature and in many cases transient or mild. Based on the efficacy and safety data on rufinamide obtained to date, this medication will provide additional benefits to patients with LGS in Canada and is an important consideration for our patients in the adjunctive treatment setting.<\/jats:p>","DOI":"10.1017\/s0317167100015535","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T15:01:57Z","timestamp":1418396517000},"page":"702-711","source":"Crossref","is-referenced-by-count":9,"title":["Lennox-Gastaut Syndrome: An Update on Treatment"],"prefix":"10.1017","volume":"39","author":[{"given":"Lionel","family":"Carmant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Whiting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2014,12,2]]},"reference":[{"key":"S0317167100015535_ref038","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200022060-00005"},{"key":"S0317167100015535_ref025","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb00179.x"},{"key":"S0317167100015535_ref027","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2009.10.007"},{"key":"S0317167100015535_ref044","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1972.tb04582.x"},{"key":"S0317167100015535_ref039","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.9.1882"},{"key":"S0317167100015535_ref016","first-page":"85","article-title":"The Lennox-Gastaut syndrome: a personal study","author":"Beaumanoir","year":"1982","journal-title":"Electroencephalogr Clin Neurophysiol Suppl"},{"key":"S0317167100015535_ref047","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb00192.x"},{"key":"S0317167100015535_ref052","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2009.07.038"},{"key":"S0317167100015535_ref033","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1982.tb05085.x"},{"key":"S0317167100015535_ref043","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01935.x"},{"key":"S0317167100015535_ref011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1993.tb04593.x"},{"key":"S0317167100015535_ref045","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2004.19704.x"},{"key":"S0317167100015535_ref053","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2007.07.013"},{"key":"S0317167100015535_ref041","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)83302-5"},{"key":"S0317167100015535_ref035","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2010.09.014"},{"key":"S0317167100015535_ref037","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100034910"},{"key":"S0317167100015535_ref019","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm002"},{"key":"S0317167100015535_ref021","volume-title":"GeneReviews","author":"Miller","year":"1993"},{"key":"S0317167100015535_ref031","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03178.x"},{"key":"S0317167100015535_ref017","first-page":"259","article-title":"Childhood epileptic encephalopathy with slow spike-wave","volume":"13","author":"Chevrie","year":"1972","journal-title":"A statistical study of 80 cases. 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