{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T13:54:08Z","timestamp":1771509248111,"version":"3.50.1"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:00:00Z","timestamp":1417478400000},"content-version":"unspecified","delay-in-days":761,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:sec id=\"S0317167100015596_abs1\"><jats:title>Background:<\/jats:title><jats:p>Vasospasm is a known complication of aneurysmal subarachnoid hemorrhage and is a major cause of neurological morbidity and mortality. It is infrequently associated with pituitary adenoma surgery. We report three cases and present a systematic review of the literature with a view towards guiding neurosurgeons in the prevention and management of this complication.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100015596_abs2\"><jats:title>Results:<\/jats:title><jats:p>Including our experience, vasospasm complicating pituitary adenoma surgery has been documented in 29 patients (mean age of 45). All cases occurred in the setting of a postoperative hemorrhage: 21 had a subarachnoid hemorrhage and 10 had a postoperative hematoma requiring evacuation. Initial clinical appearance of delayed cerebral ischemia attributable to vasospasm occurred from postoperative Days 2-13 (most commonly Day 5). Digital subtraction angiography and medical management were the most common diagnostic and therapeutic strategies, respectively. Glasgow Outcome Scores were \u22643 in 59% of cases. Univariate logistic regression identified later diagnosis of vasospasm and surgery for hematoma evacuation to be independently associated with better outcomes.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100015596_abs3\"><jats:title>Conclusion:<\/jats:title><jats:p>Vasospasm should be considered in the differential diagnosis of patients demonstrating altered mental or neurological status following pituitary surgery, particularly if there has been postoperative hemorrhage of any degree. Prompt treatment should be instituted to optimize outcome.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0317167100015596","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T15:01:57Z","timestamp":1418396517000},"page":"767-773","source":"Crossref","is-referenced-by-count":18,"title":["Vasospasm Post Pituitary Surgery: Systematic Review and 3 Case Presentations"],"prefix":"10.1017","volume":"39","author":[{"given":"Alireza","family":"Mansouri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aria","family":"Fallah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Cusimano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunit","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,12,2]]},"reference":[{"key":"S0317167100015596_ref008","first-page":"229","article-title":"Vasospasm following transcranial removal of large pituitary adenomas","volume":"50","author":"Mawk","year":"1979","journal-title":"Report of three cases"},{"key":"S0317167100015596_ref005","first-page":"353","article-title":"Balloon angioplasty to treat vasospasm after transsphenoidal surgery","volume":"95","author":"Friedman","year":"2001","journal-title":"Case illustration"},{"key":"S0317167100015596_ref023","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1990.73.1.0018"},{"key":"S0317167100015596_ref002","first-page":"318","article-title":"Surgical management of pituitary adenomas","volume":"43","author":"Jane","year":"2002","journal-title":"Singapore Med J"},{"key":"S0317167100015596_ref025","volume-title":"San Diego","author":"MacDonald","year":"2001"},{"key":"S0317167100015596_ref029","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1974.40.4.0473"},{"key":"S0317167100015596_ref013","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198010000-00012"},{"key":"S0317167100015596_ref003","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-007-1244-8"},{"key":"S0317167100015596_ref028","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009951917649"},{"key":"S0317167100015596_ref021","first-page":"972","article-title":"Vasospasm after pituitary surgery","volume":"58","author":"Mawk","year":"1980","journal-title":"J Neurosurg"},{"key":"S0317167100015596_ref011","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-011-0482-y"},{"key":"S0317167100015596_ref012","doi-asserted-by":"publisher","DOI":"10.1007\/BF01997789"},{"key":"S0317167100015596_ref016","doi-asserted-by":"publisher","DOI":"10.1136\/jnis.2010.003251.29"},{"key":"S0317167100015596_ref015","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199007000-00008"},{"key":"S0317167100015596_ref026","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-005-0013-5"},{"key":"S0317167100015596_ref020","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4103\/0028-3886.39322","article-title":"Vasospasm after transsphenoidal pituitary surgery: a case report and review of the literature","volume":"56","author":"Kasliwal","year":"2008","journal-title":"Neurology India"},{"key":"S0317167100015596_ref027","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00531-3"},{"key":"S0317167100015596_ref030","first-page":"1011","article-title":"CT angiography for the detection of cerebral vasospasm in patients with acute subarachnoid hemorrhage","volume":"21","author":"Anderson","year":"2000","journal-title":"Am J Neuroradiol"},{"key":"S0317167100015596_ref001","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.329.7459.218"},{"key":"S0317167100015596_ref004","first-page":"655","article-title":"Arterial injuries in transsphenoidal surgery for pituitary adenoma; 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