{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:20:59Z","timestamp":1790364059075,"version":"4.1.0"},"reference-count":37,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:00:00Z","timestamp":1417478400000},"content-version":"unspecified","delay-in-days":761,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can. J. Neurol. Sci."],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:sec id=\"S0317167100015638_abs1\"><jats:title>Background:<\/jats:title><jats:p>Longitudinal, patient-level data on resource use and costs after an ischemic stroke are lacking in Canada. The objectives of this analysis were to calculate costs for the first year post-stroke and determine the impact of disability on costs.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100015638_abs2\"><jats:title>Methodology:<\/jats:title><jats:p>The Economic Burden of Ischemic Stroke (BURST) Study was a one-year prospective study with a cohort of ischemic stroke patients recruited at 12 Canadian stroke centres. Clinical history, disability, health preference and resource utilization information was collected at discharge, three months, six months and one year. Resources included direct medical costs (2009 CAN$) such as emergency services, hospitalizations, rehabilitation, physician services, diagnostics, medications, allied health professional services, homecare, medical\/assistive devices, changes to residence and paid caregivers, as well as indirect costs. Results were stratified by disability measured at discharge using the modified Rankin Score (mRS): non-disabling stroke (mRS 0-2) and disabling stroke (mRS 3-5).<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100015638_abs3\"><jats:title>Results:<\/jats:title><jats:p>We enrolled 232 ischemic stroke patients (age 69.4 \u00b1 15.4 years; 51.3% male) and 113 (48.7%) were disabled at hospital discharge. The average annual cost was $74,353; $107,883 for disabling strokes and $48,339 for non-disabling strokes.<\/jats:p><\/jats:sec><jats:sec id=\"S0317167100015638_abs4\"><jats:title>Conclusions:<\/jats:title><jats:p>An average annual cost for ischemic stroke was calculated in which a disabling stroke was associated with a two-fold increase in costs compared to NDS. Costs during the hospitalization to three months phase were the highest contributor to the annual cost. A \u201cback of the envelope\u201d calculation using 38,000 stroke admissions and the average annual cost yields $2.8 billion as the burden of ischemic stroke.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0317167100015638","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T15:01:57Z","timestamp":1418396517000},"page":"793-800","source":"Crossref","is-referenced-by-count":98,"title":["Impact of Disability Status on Ischemic Stroke Costs in Canada in the First Year"],"prefix":"10.1017","volume":"39","author":[{"given":"Nicole","family":"Mittmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Jin","family":"Seung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen 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